| pubmed-article:1034220 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1034220 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1034220 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:1034220 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:1034220 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:1034220 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:1034220 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1034220 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1034220 | pubmed:dateCreated | 1977-2-16 | lld:pubmed |
| pubmed-article:1034220 | pubmed:abstractText | An extract from porcine pituitaries containing peptides with opiate-like activity (endorphins) was investigated for possible tolerance/dependence liability in rats. Repeated intraventricular administration of endorphins induced a degree of tolerance similar to that induced by normorphine. Rats made tolerant to morphine by repeated pellet implantation proved cross-tolerant to the pituitary extract as well as to synthetic methionine-enkephalin. Naloxone given to rats, repeatedly pretreated with endorphins, precipitated a withdrawal syndrome strongly resembling that induced in rats treated with normorphine. Withdrawal precipitated in morphine-dependent rats was suppressed by intraventricularly applied endorphins. The results suggest that identical sites and mechanisms are involved in the development of tolerance/dependence induced by opiates and pituitary endorphins. | lld:pubmed |
| pubmed-article:1034220 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1034220 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1034220 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1034220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1034220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1034220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1034220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1034220 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1034220 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1034220 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:1034220 | pubmed:author | pubmed-author:HerzAA | lld:pubmed |
| pubmed-article:1034220 | pubmed:author | pubmed-author:BläsigJJ | lld:pubmed |
| pubmed-article:1034220 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1034220 | pubmed:volume | 294 | lld:pubmed |
| pubmed-article:1034220 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1034220 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1034220 | pubmed:pagination | 297-300 | lld:pubmed |
| pubmed-article:1034220 | pubmed:dateRevised | 2010-3-12 | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:meshHeading | pubmed-meshheading:1034220-... | lld:pubmed |
| pubmed-article:1034220 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:1034220 | pubmed:articleTitle | Tolerance and dependence induced by morphine-like pituitary peptides in rats. | lld:pubmed |
| pubmed-article:1034220 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1034220 | lld:pubmed |
