| pubmed-article:10335918 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10335918 | lifeskim:mentions | umls-concept:C1522449 | lld:lifeskim |
| pubmed-article:10335918 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:10335918 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:10335918 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10335918 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:10335918 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10335918 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10335918 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10335918 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10335918 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10335918 | pubmed:dateCreated | 1999-6-23 | lld:pubmed |
| pubmed-article:10335918 | pubmed:abstractText | Recently, the proto-oncogenes bcl-2 and bax have emerged as important regulators of the apoptotic form of cell death. We examined UV irradiation-elicited apoptosis and regulation of bcl-2 and bax expression both in vivo in human skin and in vitro in HeLa cells. Using flow cytometric analysis, HeLa cells were found to undergo apoptosis at the 12-h time-point after exposure to UVB irradiation (100 mJ/cm2). The expression of bcl-2 mRNA was found to decrease after a single dose of UVB radiation (doses 10-200 mJ/cm2). In contrast, the expression of bax mRNA was not significantly changed. When human skin was irradiated with a single dose of solar-simulated radiation (40 mJ/cm2), Bcl-2-positive cells were significantly reduced in the epidermis at the 3- and 6-h time-points. Our results suggest that UV irradiation downregulates bcl-2 expression both in vitro at the mRNA level and in vivo at the protein level, and that downregulation of bcl-2 constitutes a mechanism of potential importance in UV-induced apoptosis in human epidermis. | lld:pubmed |
| pubmed-article:10335918 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10335918 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10335918 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10335918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10335918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10335918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10335918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10335918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10335918 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10335918 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10335918 | pubmed:issn | 0340-3696 | lld:pubmed |
| pubmed-article:10335918 | pubmed:author | pubmed-author:JansenCC | lld:pubmed |
| pubmed-article:10335918 | pubmed:author | pubmed-author:PunnonenKK | lld:pubmed |
| pubmed-article:10335918 | pubmed:author | pubmed-author:IsoherranenKK | lld:pubmed |
| pubmed-article:10335918 | pubmed:author | pubmed-author:SaurojaII | lld:pubmed |
| pubmed-article:10335918 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10335918 | pubmed:volume | 291 | lld:pubmed |
| pubmed-article:10335918 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10335918 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10335918 | pubmed:pagination | 212-6 | lld:pubmed |
| pubmed-article:10335918 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10335918 | pubmed:meshHeading | pubmed-meshheading:10335918... | lld:pubmed |
| pubmed-article:10335918 | pubmed:meshHeading | pubmed-meshheading:10335918... | lld:pubmed |
| pubmed-article:10335918 | pubmed:meshHeading | pubmed-meshheading:10335918... | lld:pubmed |
| pubmed-article:10335918 | pubmed:meshHeading | pubmed-meshheading:10335918... | lld:pubmed |
| pubmed-article:10335918 | pubmed:meshHeading | pubmed-meshheading:10335918... | lld:pubmed |
| pubmed-article:10335918 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10335918 | pubmed:articleTitle | UV irradiation induces downregulation of bcl-2 expression in vitro and in vivo. | lld:pubmed |
| pubmed-article:10335918 | pubmed:affiliation | Department of Clinical Chemistry, University of Turku, Finland. kirsi.isoherranen@huch.fi | lld:pubmed |
| pubmed-article:10335918 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10335918 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:10335918 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10335918 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10335918 | lld:pubmed |
