| pubmed-article:10329950 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10329950 | lifeskim:mentions | umls-concept:C1704336 | lld:lifeskim |
| pubmed-article:10329950 | lifeskim:mentions | umls-concept:C0521324 | lld:lifeskim |
| pubmed-article:10329950 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10329950 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:10329950 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10329950 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10329950 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:10329950 | pubmed:issue | 5 Pt 1 | lld:pubmed |
| pubmed-article:10329950 | pubmed:dateCreated | 1999-6-7 | lld:pubmed |
| pubmed-article:10329950 | pubmed:abstractText | The present study used real-time confocal microscopy to examine the effects of the beta2-adrenoceptor agonist salbutamol on regulation of intracellular Ca2+ concentration ([Ca2+]i) in myotubes derived from neonatal mouse limb muscles. Immunocytochemical staining for ryanodine receptors and skeletal muscle myosin confirmed the presence of sarcomeres. The myotubes displayed both spontaneous and ACh-induced rapid (<2-ms rise time) [Ca2+]i transients. The [Ca2+]i transients were frequency modulated by both low and high concentrations of salbutamol. Exposure to alpha-bungarotoxin and tetrodotoxin inhibited ACh-induced [Ca2+]i transients and the response to low concentrations of salbutamol but not the response to higher concentrations. Preexposure to caffeine inhibited the subsequent [Ca2+]i response to lower concentrations of salbutamol and significantly blunted the response to higher concentrations. Preexposure to salbutamol diminished the [Ca2+]i response to caffeine. Inhibition of dihydropyridine-sensitive Ca2+ channels with nifedipine or PN-200-110 did not prevent [Ca2+]i elevations induced by higher concentrations of salbutamol. The effects of salbutamol were mimicked by the membrane-permeant analog dibutyryl adenosine 3', 5'-cyclic monophosphate. These data indicate that salbutamol effects in skeletal muscle predominantly involve enhanced sarcoplasmic reticulum Ca2+ release. | lld:pubmed |
| pubmed-article:10329950 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10329950 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10329950 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10329950 | pubmed:month | May | lld:pubmed |
| pubmed-article:10329950 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:10329950 | pubmed:author | pubmed-author:SieckG CGC | lld:pubmed |
| pubmed-article:10329950 | pubmed:author | pubmed-author:GallantE MEM | lld:pubmed |
| pubmed-article:10329950 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:10329950 | pubmed:author | pubmed-author:PrakashY SYS | lld:pubmed |
| pubmed-article:10329950 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10329950 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:10329950 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10329950 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10329950 | pubmed:pagination | C1038-45 | lld:pubmed |
| pubmed-article:10329950 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:meshHeading | pubmed-meshheading:10329950... | lld:pubmed |
| pubmed-article:10329950 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10329950 | pubmed:articleTitle | Effect of beta-adrenoceptor activation on [Ca2+]i regulation in murine skeletal myotubes. | lld:pubmed |
| pubmed-article:10329950 | pubmed:affiliation | Departments of Anesthesiology and of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester 55905, Minnesota, USA. | lld:pubmed |
| pubmed-article:10329950 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10329950 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10329950 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10329950 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10329950 | lld:pubmed |
