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| pubmed-article:10329646 | lifeskim:mentions | umls-concept:C1826448 | lld:lifeskim |
| pubmed-article:10329646 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:10329646 | pubmed:dateCreated | 1999-7-9 | lld:pubmed |
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| pubmed-article:10329646 | pubmed:abstractText | Ced-4 and Apaf-1 belong to a major class of apoptosis regulators that contain caspase-recruitment (CARD) and nucleotide-binding oligomerization domains. Nod1, a protein with an NH2-terminal CARD-linked to a nucleotide-binding domain and a COOH-terminal segment with multiple leucine-rich repeats, was identified. Nod-1 was found to bind to multiple caspases with long prodomains, but specifically activated caspase-9 and promoted caspase-9-induced apoptosis. As reported for Apaf-1, Nod1 required both the CARD and P-loop for function. Unlike Apaf-1, Nod1 induced activation of nuclear factor-kappa-B (NF-kappaB) and bound RICK, a CARD-containing kinase that also induces NF-kappaB activation. Nod1 mutants inhibited NF-kappaB activity induced by RICK, but not that resulting from tumor necrosis factor-alpha stimulation. Thus, Nod1 is a leucine-rich repeat-containing Apaf-1-like molecule that can regulate both apoptosis and NF-kappaB activation pathways. | lld:pubmed |
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| pubmed-article:10329646 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10329646 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10329646 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10329646 | pubmed:month | May | lld:pubmed |
| pubmed-article:10329646 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10329646 | pubmed:author | pubmed-author:ChenSS | lld:pubmed |
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| pubmed-article:10329646 | pubmed:author | pubmed-author:ORRS HSH | lld:pubmed |
| pubmed-article:10329646 | pubmed:author | pubmed-author:KosekiTT | lld:pubmed |
| pubmed-article:10329646 | pubmed:author | pubmed-author:InoharaNN | lld:pubmed |
| pubmed-article:10329646 | pubmed:author | pubmed-author:NúñezGG | lld:pubmed |
| pubmed-article:10329646 | pubmed:author | pubmed-author:del PesoLL | lld:pubmed |
| pubmed-article:10329646 | pubmed:author | pubmed-author:CarrioRR | lld:pubmed |
| pubmed-article:10329646 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10329646 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10329646 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10329646 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10329646 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10329646 | pubmed:pagination | 14560-7 | lld:pubmed |
| pubmed-article:10329646 | pubmed:dateRevised | 2008-5-7 | lld:pubmed |
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| pubmed-article:10329646 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10329646 | pubmed:articleTitle | Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. | lld:pubmed |
| pubmed-article:10329646 | pubmed:affiliation | Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | lld:pubmed |
| pubmed-article:10329646 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10329646 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10329646 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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