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pubmed-article:10328301pubmed:abstractTextA 13-C labeled water soluble derivative of alkylcatechol was synthesized and reacted with human serum albumin in phosphate buffer at pH 7.4 in air to allow a slow oxidation of the catechol into orthoquinone. The formation of several adducts was evidenced by a combination of 13C and 1H-13C correlation NMR. Although some adducts could result from a classical o-quinone formation - Michael type addition, our results suggest that a second pathway, involving a direct reaction of a carbon centered radical with proteins could be an important mechanism in the formation of modified proteins.lld:pubmed
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pubmed-article:10328301pubmed:pagination1141-6lld:pubmed
pubmed-article:10328301pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10328301pubmed:year1999lld:pubmed
pubmed-article:10328301pubmed:articleTitleSynthesis of a water-soluble analog of 6-methyl-3-N-alkyl catechol labeled with carbon 13: NMR approach to the reactivity of poison ivy/oak sensitizers toward proteins.lld:pubmed
pubmed-article:10328301pubmed:affiliationLaboratoire de Dermatochimie associé au CNRS, Université Louis Pasteur, Clinique Dermatologique, CHU, Strasbourg, France.lld:pubmed
pubmed-article:10328301pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10328301pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed