pubmed-article:10327051 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C0162508 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1332119 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1333336 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1552126 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1709313 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
pubmed-article:10327051 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
pubmed-article:10327051 | pubmed:issue | 14 | lld:pubmed |
pubmed-article:10327051 | pubmed:dateCreated | 1999-6-3 | lld:pubmed |
pubmed-article:10327051 | pubmed:abstractText | The adenovirus E1A proteins activate the c-jun promoter through two Jun/ATF-binding sites, jun1 and jun2. P300, a transcriptional coactivator of several AP1 and ATF transcription factors has been postulated to play a role in this activation. Here, we present evidence that p300 can control c-jun transcription by acting as a cofactor for ATF2: (1) Over-expression of p300 was found to stimulate c-jun transcription both in the presence and absence of E1A. (2) Like E1A, p300 activates the c-jun promoter through the junl and jun2 elements and preferentially activates the N-terminal domain of ATF2. (3) Co-immunoprecipitation assays of crude cell extracts indicate that endogenous p300/CBP(-like) proteins and ATF2 proteins are present in a multiprotein complex that can bind specifically to the jun2 element. We further demonstrate that the Stress-Activated-Protein-Kinase (SAPK) target sites of ATF2, Thr69 and Thr71 are not required for the formation of the p300/CBP-ATF2 multiprotein complex. These data indicate that E1A does not inhibit all transcription activation functions of p300, and, in fact, cooperates with p300 in the activation of the ATF2 N-terminus. | lld:pubmed |
pubmed-article:10327051 | pubmed:language | eng | lld:pubmed |
pubmed-article:10327051 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10327051 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:10327051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10327051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10327051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10327051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10327051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:10327051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:10327051 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10327051 | pubmed:month | Apr | lld:pubmed |
pubmed-article:10327051 | pubmed:issn | 0950-9232 | lld:pubmed |
pubmed-article:10327051 | pubmed:author | pubmed-author:ZantemaAA | lld:pubmed |
pubmed-article:10327051 | pubmed:author | pubmed-author:van DamHH | lld:pubmed |
pubmed-article:10327051 | pubmed:author | pubmed-author:van der EbA... | lld:pubmed |
pubmed-article:10327051 | pubmed:author | pubmed-author:SmithP EPE | lld:pubmed |
pubmed-article:10327051 | pubmed:author | pubmed-author:DuyndamM CMC | lld:pubmed |
pubmed-article:10327051 | pubmed:author | pubmed-author:VerlaanMM | lld:pubmed |
pubmed-article:10327051 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10327051 | pubmed:day | 8 | lld:pubmed |
pubmed-article:10327051 | pubmed:volume | 18 | lld:pubmed |
pubmed-article:10327051 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10327051 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10327051 | pubmed:pagination | 2311-21 | lld:pubmed |
pubmed-article:10327051 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:10327051 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10327051 | pubmed:articleTitle | The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A. | lld:pubmed |
pubmed-article:10327051 | pubmed:affiliation | Laboratory for Molecular Carcinogenesis, Leiden University Medical Center, The Netherlands. | lld:pubmed |
pubmed-article:10327051 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10327051 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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