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pubmed-article:1032280pubmed:abstractTextThe biological activity of a rat ascites leukaemia subline isolated by isopycnic centrifugation was compared to that of the original tumour both in vivo and in vitro. The subline had different marker chromosomes, a longer cell cycle time and decreased sensitivity to vinblastine as compared to the original tumour.lld:pubmed
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pubmed-article:1032280pubmed:articleTitleThe role of heterogeneity of tumour cell populations in biological activity and sensitivity to chemotherapeutics.lld:pubmed
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