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pubmed-article:10320769pubmed:abstractTextCalbindin-D28K (CALB) in the medial basal hypothalamic (MBH) and preoptic area (POA) of male and female fetuses from pregnant rats fed different phytoestrogens diets during gestation was examined by Western analysis. In animals fed a phytoestrogen containing diet (Phyto-200), males displayed significantly higher CALB levels compared to females. Whereas, in animals fed a phytoestrogen-free diet (Phyto-free), females exhibited significantly higher CALB levels compared to Phyto-200 female values. The present data have far reaching implications where phytoestrogen content in diets apparently influence MBH-POA CALB levels prenatally. The altered CALB levels may in turn modify sexually dimorphic brain structures during neuronal development by buffering Ca2+ that is associated with programmed cell death.lld:pubmed
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pubmed-article:10320769pubmed:authorpubmed-author:TaylorHHlld:pubmed
pubmed-article:10320769pubmed:authorpubmed-author:LephartE DEDlld:pubmed
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pubmed-article:10320769pubmed:authorpubmed-author:QuinteroE MEMlld:pubmed
pubmed-article:10320769pubmed:copyrightInfoCopyright 1999 Elsevier Science B.V.lld:pubmed
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pubmed-article:10320769pubmed:volume114lld:pubmed
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pubmed-article:10320769pubmed:pagination277-81lld:pubmed
pubmed-article:10320769pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10320769pubmed:articleTitlePhytoestrogens alter hypothalamic calbindin-D28k levels during prenatal development.lld:pubmed
pubmed-article:10320769pubmed:affiliationDepartment of Zoology, Cellular Biology Division, Brigham Young University, Provo, UT 84602, USA.lld:pubmed
pubmed-article:10320769pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10320769pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:10320769pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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