| pubmed-article:10319817 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C0040005 | lld:lifeskim |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C0043481 | lld:lifeskim |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C0205681 | lld:lifeskim |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:10319817 | lifeskim:mentions | umls-concept:C0077368 | lld:lifeskim |
| pubmed-article:10319817 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10319817 | pubmed:dateCreated | 1999-5-20 | lld:pubmed |
| pubmed-article:10319817 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10319817 | pubmed:abstractText | E. coli threonyl-tRNA synthetase (ThrRS) is a class II enzyme that represses the translation of its own mRNA. We report the crystal structure at 2.9 A resolution of the complex between tRNA(Thr) and ThrRS, whose structural features reveal novel strategies for providing specificity in tRNA selection. These include an amino-terminal domain containing a novel protein fold that makes minor groove contacts with the tRNA acceptor stem. The enzyme induces a large deformation of the anticodon loop, resulting in an interaction between two adjacent anticodon bases, which accounts for their prominent role in tRNA identity and translational regulation. A zinc ion found in the active site is implicated in amino acid recognition/discrimination. | lld:pubmed |
| pubmed-article:10319817 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10319817 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10319817 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10319817 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10319817 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10319817 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:10319817 | pubmed:author | pubmed-author:SpringerMM | lld:pubmed |
| pubmed-article:10319817 | pubmed:author | pubmed-author:ReesBB | lld:pubmed |
| pubmed-article:10319817 | pubmed:author | pubmed-author:MorayNN | lld:pubmed |
| pubmed-article:10319817 | pubmed:author | pubmed-author:CailletJJ | lld:pubmed |
| pubmed-article:10319817 | pubmed:author | pubmed-author:EhresmannCC | lld:pubmed |
| pubmed-article:10319817 | pubmed:author | pubmed-author:EhresmannBB | lld:pubmed |
| pubmed-article:10319817 | pubmed:author | pubmed-author:RombyPP | lld:pubmed |
| pubmed-article:10319817 | pubmed:author | pubmed-author:Sankaranaraya... | lld:pubmed |
| pubmed-article:10319817 | pubmed:author | pubmed-author:Dock-BregeonA... | lld:pubmed |
| pubmed-article:10319817 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10319817 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:10319817 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:10319817 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10319817 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10319817 | pubmed:pagination | 371-81 | lld:pubmed |
| pubmed-article:10319817 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10319817 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10319817 | pubmed:articleTitle | The structure of threonyl-tRNA synthetase-tRNA(Thr) complex enlightens its repressor activity and reveals an essential zinc ion in the active site. | lld:pubmed |
| pubmed-article:10319817 | pubmed:affiliation | UPR 9004 Biologie Structurale, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France. | lld:pubmed |
| pubmed-article:10319817 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10319817 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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