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pubmed-article:10233192pubmed:abstractTextWe have previously shown that 70% of patients experience nocturnal gastric acid breakthrough (defined as pH<4 for more than 60 min between 22.00 and 06.00 hours) on twice a day (b.d.) proton pump inhibitor. Adding 150 or 300 mg of ranitidine at bedtime is more effective than additional omeprazole at bedtime in control of night-time acid breakthrough.lld:pubmed
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pubmed-article:10233192pubmed:articleTitleBedtime ranitidine does not eliminate the need for a second daily dose of omeprazole to suppress nocturnal gastric pH.lld:pubmed
pubmed-article:10233192pubmed:affiliationDepartment of Medicine, The Graduate Hospital, Philadelphia, Pennsylvania 19146, USA.lld:pubmed
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