| pubmed-article:10233027 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10233027 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:10233027 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:10233027 | lifeskim:mentions | umls-concept:C1154417 | lld:lifeskim |
| pubmed-article:10233027 | lifeskim:mentions | umls-concept:C1513371 | lld:lifeskim |
| pubmed-article:10233027 | pubmed:issue | 5 Pt 2 | lld:pubmed |
| pubmed-article:10233027 | pubmed:dateCreated | 1999-6-3 | lld:pubmed |
| pubmed-article:10233027 | pubmed:abstractText | The neuroendocrine mechanisms by which estradiol drives growth hormone (GH) secretion in the human are poorly defined. Here we investigate estrogen's specific regulation of the 24-h pulsatile, nyctohemeral, and entropic modes of GH secretion in healthy postmenopausal women. Volunteers (n = 9) received randomly ordered placebo versus estradiol-17beta (1 mg micronized steroid twice daily orally) treatment for 7-10 days and underwent blood sampling at 10-min intervals for 24 h to capture GH release profiles quantitated in a high-sensitivity chemiluminescence assay. Pulsatile GH secretion was appraised via deconvolution analysis, nyctohemeral GH rhythms by cosinor analysis, and the orderliness of GH release patterns via the approximate entropy statistic. Mean (+/-SE) 24-h serum GH concentrations approximately doubled on estrogen treatment (viz., from 0.31 +/- 0.03 to 0.51 +/- 0.07 microgram/l; P = 0.033). Concomitantly, serum insulin-like growth factor-I (IGF-I), luteinizing hormone, and follicle-stimulating hormone concentrations fell, whereas thyroid-stimulating hormone and prolactin levels rose (P < 0.01). The specific neuroendocrine action of estradiol included 1) a twofold amplified mass of GH secreted per burst, with no significant changes in basal GH release, half-life, pulse frequency, or duration; 2) an augmented amplitude and mesor of the 24-h rhythm in GH release, with no alteration in acrophase; and 3) greater disorderliness of GH release (higher approximate entropy). These distinctive and dynamic reactions to estrogen are consistent with partial withdrawal of IGF-I's negative feedback and/or accentuated central drive to GH secretion. | lld:pubmed |
| pubmed-article:10233027 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233027 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233027 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233027 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10233027 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233027 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10233027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10233027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233027 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10233027 | pubmed:month | May | lld:pubmed |
| pubmed-article:10233027 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:10233027 | pubmed:author | pubmed-author:VeldhuisJ DJD | lld:pubmed |
| pubmed-article:10233027 | pubmed:author | pubmed-author:ShahNN | lld:pubmed |
| pubmed-article:10233027 | pubmed:author | pubmed-author:EvansW SWS | lld:pubmed |
| pubmed-article:10233027 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10233027 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:10233027 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10233027 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10233027 | pubmed:pagination | R1351-8 | lld:pubmed |
| pubmed-article:10233027 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10233027 | pubmed:meshHeading | pubmed-meshheading:10233027... | lld:pubmed |
| pubmed-article:10233027 | pubmed:meshHeading | pubmed-meshheading:10233027... | lld:pubmed |
| pubmed-article:10233027 | pubmed:meshHeading | pubmed-meshheading:10233027... | lld:pubmed |
| pubmed-article:10233027 | pubmed:meshHeading | pubmed-meshheading:10233027... | lld:pubmed |
| pubmed-article:10233027 | pubmed:meshHeading | pubmed-meshheading:10233027... | lld:pubmed |
| pubmed-article:10233027 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10233027 | pubmed:articleTitle | Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion. | lld:pubmed |
| pubmed-article:10233027 | pubmed:affiliation | Division of Endocrinology and Metabolism, Department of Internal Medicine and National Science Foundation Center for Biological Timing, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA. | lld:pubmed |
| pubmed-article:10233027 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10233027 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10233027 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10233027 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
| pubmed-article:10233027 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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