Linked Life Data

10229585

Source:http://linkedlifedata.com/resource/pubmed/id/10229585

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SubjectPredicateObjectContext
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pubmed-article:10229585pubmed:abstractTextA leading cause of morbidity from bacterial meningitis is an irreversible, usually profound sensorineural hearing loss, with an incidence as high as 30% in some studies. Bacterial meningitis remains the most common cause of acquired postnatal sensorineural deafness. Although several clinical studies have examined the long-term outcome of hearing in meningitis, few studies have examined the time course of hearing loss during the acute course of the disease. We have developed an animal model of meningogenic hearing loss in the rat and have plotted the time course of that hearing loss. Serial auditory brain stem responses (ABRs) were measured in rats inoculated in the cisterna magna (subarachnoid space) with Streptococcus pneumoniae (10(5) to 10(7) colony-forming units). All rats injected developed meningitis as evidenced by increased cerebrospinal fluid (CSF) white cell counts and positive CSF cultures. Serial ABR measurements taken 6, 12, 15, 18, 21, and 24 hours after inoculation demonstrated significant threshold shifts and eventual loss of the ABR waveform as compared with measurements in control rats injected with sterile culture medium. Hearing loss began approximately 12 to 15 hours after inoculation and progressed to complete loss by 24 hours (17 of 18 animals). No correlation was found between the magnitude of hearing loss and CSF white cell count or bacterial titer. Temporal bone histology of rats with meningitis shows a dense inflammatory cell infiltrate throughout the subarachnoid space. Labyrinthine inflammatory cells were confined to the scala tympani. The cochlear aqueduct is the proposed route of infection from the meninges to the labyrinth (scala tympani). Endolymphatic hydrops was also noted throughout the cochlea. These experiments both establish a reproducible animal model of meningogenic hearing loss and support the hypothesis that this hearing loss is progressive rather than abrupt in onset and is related to the duration of untreated infection. CSF inflammatory cells appear to enter the cochlea through the cochlear aqueduct. This reliable animal model will enable future studies directed toward further understanding the pathogenesis and pathophysiology of this hearing loss.lld:pubmed
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pubmed-article:10229585pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10229585pubmed:year1999lld:pubmed
pubmed-article:10229585pubmed:articleTitleTime course of hearing loss in an animal model of pneumococcal meningitis.lld:pubmed
pubmed-article:10229585pubmed:affiliationDepartment of Otolaryngology-Head and Neck Surgery, University of Virginia Medical Center, Charlottesville 22908, USA.lld:pubmed
pubmed-article:10229585pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10229585pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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