| pubmed-article:10224289 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C0253023 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C1719914 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C2828406 | lld:lifeskim |
| pubmed-article:10224289 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:10224289 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10224289 | pubmed:dateCreated | 1999-6-15 | lld:pubmed |
| pubmed-article:10224289 | pubmed:abstractText | During HIV/SIV infection, there is widespread programmed cell death in infected and, perhaps more importantly, uninfected cells. Much of this apoptosis is mediated by Fas-Fas ligand (FasL) interactions. Previously we demonstrated in macaques that induction of FasL expression and apoptotic cell death of both CD4(+) and CD8(+) T cells by SIV is dependent on a functional nef gene. However, the molecular mechanism whereby HIV-1 induces the expression of FasL remained poorly understood. Here we report a direct association of HIV-1 Nef with the zeta chain of the T cell receptor (TCR) complex and the requirement of both proteins for HIV-mediated upregulation of FasL. Expression of FasL through Nef depended upon the integrity of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the TCR zeta chain. Conformation for the importance of zeta for Nef-mediated signaling in T cells came from an independent finding. A single ITAM motif of zeta but not CD3epsilon was both required and sufficient to promote activation and binding of the Nef-associated kinase (NAK/p62). Our data imply that Nef can form a signaling complex with the TCR, which bypasses the requirement of antigen to initiate T cell activation and subsequently upregulation of FasL expression. Thus, our study may provide critical insights into the molecular mechanism whereby the HIV-1 accessory protein Nef contributes to the pathogenesis of HIV. | lld:pubmed |
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| pubmed-article:10224289 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10224289 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224289 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10224289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10224289 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10224289 | pubmed:month | May | lld:pubmed |
| pubmed-article:10224289 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:10224289 | pubmed:author | pubmed-author:WoldFF | lld:pubmed |
| pubmed-article:10224289 | pubmed:author | pubmed-author:McMichaelA... | lld:pubmed |
| pubmed-article:10224289 | pubmed:author | pubmed-author:KraftMM | lld:pubmed |
| pubmed-article:10224289 | pubmed:author | pubmed-author:KolanusWW | lld:pubmed |
| pubmed-article:10224289 | pubmed:author | pubmed-author:ScreatonG RGR | lld:pubmed |
| pubmed-article:10224289 | pubmed:author | pubmed-author:SrpJJ | lld:pubmed |
| pubmed-article:10224289 | pubmed:author | pubmed-author:BaurA SAS | lld:pubmed |
| pubmed-article:10224289 | pubmed:author | pubmed-author:LaffertBB | lld:pubmed |
| pubmed-article:10224289 | pubmed:author | pubmed-author:MongkolsapayJ... | lld:pubmed |
| pubmed-article:10224289 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10224289 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:10224289 | pubmed:volume | 189 | lld:pubmed |
| pubmed-article:10224289 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10224289 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10224289 | pubmed:pagination | 1489-96 | lld:pubmed |
| pubmed-article:10224289 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10224289 | pubmed:meshHeading | pubmed-meshheading:10224289... | lld:pubmed |
| pubmed-article:10224289 | pubmed:meshHeading | pubmed-meshheading:10224289... | lld:pubmed |
| pubmed-article:10224289 | pubmed:meshHeading | pubmed-meshheading:10224289... | lld:pubmed |
| pubmed-article:10224289 | pubmed:meshHeading | pubmed-meshheading:10224289... | lld:pubmed |
