| pubmed-article:10224252 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10224252 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:10224252 | lifeskim:mentions | umls-concept:C0023980 | lld:lifeskim |
| pubmed-article:10224252 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10224252 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10224252 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10224252 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10224252 | pubmed:dateCreated | 1999-7-12 | lld:pubmed |
| pubmed-article:10224252 | pubmed:abstractText | Replicative capacity, which is the number of times an individual cell divides, is the measure of longevity in the yeast Saccharomyces cerevisiae. In this study, a process that involves signaling from the mitochondrion to the nucleus, called retrograde regulation, is shown to determine yeast longevity, and its induction resulted in postponed senescence. Activation of retrograde regulation, by genetic and environmental means, correlated with increased replicative capacity in four different S. cerevisiae strains. Deletion of a gene required for the retrograde response, RTG2, eliminated the increased replicative capacity. RAS2, a gene previously shown to influence longevity in yeast, interacts with retrograde regulation in setting yeast longevity. The molecular mechanism of aging elucidated here parallels the results of genetic studies of aging in nematodes and fruit flies, as well as the caloric restriction paradigm in mammals, and it underscores the importance of metabolic regulation in aging, suggesting a general applicability. | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10224252 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10224252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10224252 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10224252 | pubmed:month | May | lld:pubmed |
| pubmed-article:10224252 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:10224252 | pubmed:author | pubmed-author:KimSS | lld:pubmed |
| pubmed-article:10224252 | pubmed:author | pubmed-author:JazwinskiS... | lld:pubmed |
| pubmed-article:10224252 | pubmed:author | pubmed-author:LaiC YCY | lld:pubmed |
| pubmed-article:10224252 | pubmed:author | pubmed-author:KirchmanP APA | lld:pubmed |
| pubmed-article:10224252 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10224252 | pubmed:volume | 152 | lld:pubmed |
| pubmed-article:10224252 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10224252 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10224252 | pubmed:pagination | 179-90 | lld:pubmed |
| pubmed-article:10224252 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
| pubmed-article:10224252 | pubmed:meshHeading | pubmed-meshheading:10224252... | lld:pubmed |
