pubmed-article:10224129 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10224129 | lifeskim:mentions | umls-concept:C0147139 | lld:lifeskim |
pubmed-article:10224129 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
pubmed-article:10224129 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
pubmed-article:10224129 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
pubmed-article:10224129 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:10224129 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
pubmed-article:10224129 | lifeskim:mentions | umls-concept:C0205275 | lld:lifeskim |
pubmed-article:10224129 | pubmed:issue | 19 | lld:pubmed |
pubmed-article:10224129 | pubmed:dateCreated | 1999-6-3 | lld:pubmed |
pubmed-article:10224129 | pubmed:abstractText | One of the primary points of regulation of transforming growth factor-beta (TGF-beta) activity is control of its conversion from the latent precursor to the biologically active form. We have identified thrombospondin-1 as a major physiological regulator of latent TGF-beta activation. Activation is dependent on the interaction of a specific sequence in thrombospondin-1 (K412RFK415) with the latent TGF-beta complex. Platelet thrombospon-din-1 has TGF-beta activity and immunoreactive mature TGF-beta associated with it. We now report that the latency-associated peptide (LAP) of the latent TGF-beta complex also interacts with thrombospondin-1 as part of a biologically active complex. Thrombospondin.LAP complex formation involves the activation sequence of thrombospondin-1 (KRFK) and a sequence (LSKL) near the amino terminus of LAP that is conserved in TGF-beta1-5. The interactions of LAP with thrombospondin-1 through the LSKL and KRFK sequences are important for thrombospondin-mediated activation of latent TGF-beta since LSKL peptides can competitively inhibit latent TGF-beta activation by thrombospondin or KRFK-containing peptides. In addition, the association of LAP with thrombospondin-1 may function to prevent the re-formation of an inactive LAP.TGF-beta complex since thrombospondin-bound LAP no longer confers latency on active TGF-beta. The mechanism of TGF-beta activation by thrombospondin-1 appears to be conserved among TGF-beta isoforms as latent TGF-beta2 can also be activated by thrombospondin-1 or KRFK peptides in a manner that is sensitive to inhibition by LSKL peptides. | lld:pubmed |
pubmed-article:10224129 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10224129 | pubmed:language | eng | lld:pubmed |
pubmed-article:10224129 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10224129 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:10224129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10224129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10224129 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10224129 | pubmed:month | May | lld:pubmed |
pubmed-article:10224129 | pubmed:issn | 0021-9258 | lld:pubmed |
pubmed-article:10224129 | pubmed:author | pubmed-author:NatyshakII | lld:pubmed |
pubmed-article:10224129 | pubmed:author | pubmed-author:Murphy-Ullric... | lld:pubmed |
pubmed-article:10224129 | pubmed:author | pubmed-author:Schultz-Cherr... | lld:pubmed |
pubmed-article:10224129 | pubmed:author | pubmed-author:RibeiroS MSM | lld:pubmed |
pubmed-article:10224129 | pubmed:author | pubmed-author:PoczatekMM | lld:pubmed |
pubmed-article:10224129 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10224129 | pubmed:day | 7 | lld:pubmed |
pubmed-article:10224129 | pubmed:volume | 274 | lld:pubmed |
pubmed-article:10224129 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10224129 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10224129 | pubmed:pagination | 13586-93 | lld:pubmed |
pubmed-article:10224129 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:10224129 | pubmed:meshHeading | pubmed-meshheading:10224129... | lld:pubmed |
pubmed-article:10224129 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10224129 | pubmed:articleTitle | The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta. | lld:pubmed |
pubmed-article:10224129 | pubmed:affiliation | Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA. ribeiro@path.uab.edu | lld:pubmed |
pubmed-article:10224129 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10224129 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:10224129 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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