| pubmed-article:10218149 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10218149 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:10218149 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:10218149 | lifeskim:mentions | umls-concept:C0019932 | lld:lifeskim |
| pubmed-article:10218149 | lifeskim:mentions | umls-concept:C0014272 | lld:lifeskim |
| pubmed-article:10218149 | lifeskim:mentions | umls-concept:C0009148 | lld:lifeskim |
| pubmed-article:10218149 | lifeskim:mentions | umls-concept:C0040577 | lld:lifeskim |
| pubmed-article:10218149 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10218149 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:10218149 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:10218149 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10218149 | pubmed:dateCreated | 1999-7-6 | lld:pubmed |
| pubmed-article:10218149 | pubmed:abstractText | This study was conducted to investigate the physiological consequences of long-term moderate cobalt deficiency in beef cattle, which have not hitherto been studied in detail. Cobalt deficiency was induced in cattle by feeding two groups of animals either a basal corn silage-based diet that was moderately low in cobalt (83 micrograms Co/kg), or the same diet supplemented with cobalt to a total of 200 micrograms per kg, for 43 weeks. Cobalt deficiency was induced, as judged by inappetance, diminished growth gain and a markedly reduced vitamin B12 status in serum and liver. The long-term cobalt deprivation which was primarily a combination of reduced feed intake and a tissue vitamin B12 deficiency did not show evidence of a significant dysfunction of energy metabolism. The activities of glucose-6-phosphate dehydrogenase and cytochrome oxidase in liver remained unaffected by cobalt deficiency, nor was there a significant change in serum glucose level of cattle on the cobalt-deprived diet. However, analysis of thyroid hormone status indicated a slight reduction of type I thyroxine monodeiodinase activity in liver accompanied by a significant reduction of the triiodothyronine level in serum. The diminished liver vitamin B12 level resulted in significantly reduced folate level in this tissue, reduced concentrations of heme-depending blood parameters. Moreover cobalt deficiency or rather vitamin B12 deficiency was accompanied by a dramatic accumulation of the trace elements iron and nickel in liver. These results indicate that long-term moderate cobalt deficiency may induce a number of physiological changes in cattle, but a follow-up study, which excluded different feed levels by including a pair-fed control group, will be necessary to actually obtain the single effect of cobalt deficiency in cattle. | lld:pubmed |
| pubmed-article:10218149 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10218149 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10218149 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10218149 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10218149 | pubmed:issn | 0300-9831 | lld:pubmed |
| pubmed-article:10218149 | pubmed:author | pubmed-author:KirchgessnerM... | lld:pubmed |
| pubmed-article:10218149 | pubmed:author | pubmed-author:SchwarzF JFJ | lld:pubmed |
| pubmed-article:10218149 | pubmed:author | pubmed-author:StanglG IGI | lld:pubmed |
| pubmed-article:10218149 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10218149 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:10218149 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10218149 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10218149 | pubmed:pagination | 120-6 | lld:pubmed |
| pubmed-article:10218149 | pubmed:dateRevised | 2007-2-21 | lld:pubmed |
| pubmed-article:10218149 | pubmed:meshHeading | pubmed-meshheading:10218149... | lld:pubmed |
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| pubmed-article:10218149 | pubmed:meshHeading | pubmed-meshheading:10218149... | lld:pubmed |
| pubmed-article:10218149 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10218149 | pubmed:articleTitle | Cobalt deficiency effects on trace elements, hormones and enzymes involved in energy metabolism of cattle. | lld:pubmed |
| pubmed-article:10218149 | pubmed:affiliation | Institut für Ernährungsphysiologie, Technische Universität München, Freising-Weihenstephan, Germany. | lld:pubmed |
| pubmed-article:10218149 | pubmed:publicationType | Journal Article | lld:pubmed |
