| pubmed-article:10213924 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C0002210 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C0040132 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C0920350 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C0007613 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C1307640 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C0681829 | lld:lifeskim |
| pubmed-article:10213924 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:10213924 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10213924 | pubmed:dateCreated | 1999-6-10 | lld:pubmed |
| pubmed-article:10213924 | pubmed:abstractText | Experimental autoimmune thyroiditis was induced in transgenic mice (TG-3) producing human alpha-fetoprotein (AFP) and in control mice by immunization of porcine thyroid peroxidase (TPO). Development of thyroiditis accompanied with mononuclear cell infiltration was observed in 6 out of 8 treated control mice. In contrast, the development was significantly suppressed in TG-3 mice and mild histologic change was observed in only 1 out of 8 TG-3 mice (p < 0. 05). Serum anti-TPO antibody titers gradually increased in TG-3 mice as well as in control mice and there were no significant differences. In vitro phytohemagglutinin response of splenocytes from TG-3 mice was lower than that from control mice. Significantly reduced numbers of CD4+ and CD8+ splenocytes, total thymocytes, and CD4+ thymocytes were found in the nontreated TG-3 mice as compared with those in control mice. These results suggest that ubiquitously produced AFP modulates in vivo T cell development and/or T cell-dependent immune responses. | lld:pubmed |
| pubmed-article:10213924 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10213924 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10213924 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10213924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10213924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10213924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10213924 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10213924 | pubmed:issn | 1010-4283 | lld:pubmed |
| pubmed-article:10213924 | pubmed:author | pubmed-author:NishiSS | lld:pubmed |
| pubmed-article:10213924 | pubmed:author | pubmed-author:OhtakiSS | lld:pubmed |
| pubmed-article:10213924 | pubmed:author | pubmed-author:KanoAA | lld:pubmed |
| pubmed-article:10213924 | pubmed:author | pubmed-author:KotaniTT | lld:pubmed |
| pubmed-article:10213924 | pubmed:author | pubmed-author:OgataAA | lld:pubmed |
| pubmed-article:10213924 | pubmed:author | pubmed-author:MatsuuraEE | lld:pubmed |
| pubmed-article:10213924 | pubmed:author | pubmed-author:KitakawaHH | lld:pubmed |
| pubmed-article:10213924 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10213924 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:10213924 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10213924 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10213924 | pubmed:pagination | 162-71 | lld:pubmed |
| pubmed-article:10213924 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:meshHeading | pubmed-meshheading:10213924... | lld:pubmed |
| pubmed-article:10213924 | pubmed:articleTitle | Modulation of T cell function by alpha-fetoprotein: An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein. | lld:pubmed |
| pubmed-article:10213924 | pubmed:affiliation | Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan. | lld:pubmed |
| pubmed-article:10213924 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10213924 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10213924 | lld:pubmed |
