| pubmed-article:10212298 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C0376604 | lld:lifeskim |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C0521428 | lld:lifeskim |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C0234402 | lld:lifeskim |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C1372327 | lld:lifeskim |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C1552514 | lld:lifeskim |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:10212298 | lifeskim:mentions | umls-concept:C0336809 | lld:lifeskim |
| pubmed-article:10212298 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10212298 | pubmed:dateCreated | 1999-5-7 | lld:pubmed |
| pubmed-article:10212298 | pubmed:abstractText | Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that affects neurotransmitter release at peripheral synapses. LEMS antibodies inhibit Ca2+ currents in excitable cells, but it is not known whether there are additional effects on stimulus-secretion coupling. The effect of LEMS antibodies on Ca2+ currents and exocytosis was studied in bovine adrenal chromaffin cells using whole-cell voltage clamp in perforated-patch recordings. Purified LEMS IgGs from five patients inhibited N- and P/Q-type Ca2+ current components to different extents. The reduction in Ca2+ current resulted in smaller exocytotic responses to single depolarizing pulses, but the normal relationship between integrated Ca2+ entry and exocytosis (Enisch and Nowycky, 1996) was preserved. The hallmark of LEMS is a large potentiation of neuromuscular transmission after high-frequency stimulation. In chromaffin cells, stimulus trains can induce activity-dependent enhancement of the Ca2+-exocytosis relationship. Enhancement during trains occurs most frequently when pulses are brief and evoke very small amounts of Ca2+ entry (Engisch et al., 1997). LEMS antibody treatment increased the percentage of trains eliciting enhancement through two mechanisms: (1) by reducing Ca2+ entry and (2) through a Ca2+-independent effect on the process of enhancement. This leads to a paradoxical increase in the amount of exocytosis during stimulus trains, despite inhibition of Ca2+ currents. | lld:pubmed |
| pubmed-article:10212298 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10212298 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10212298 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10212298 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10212298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10212298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10212298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10212298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10212298 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10212298 | pubmed:month | May | lld:pubmed |
| pubmed-article:10212298 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:10212298 | pubmed:author | pubmed-author:NowyckyM CMC | lld:pubmed |
| pubmed-article:10212298 | pubmed:author | pubmed-author:ReedR BRB | lld:pubmed |
| pubmed-article:10212298 | pubmed:author | pubmed-author:CookNN | lld:pubmed |
| pubmed-article:10212298 | pubmed:author | pubmed-author:EngischK LKL | lld:pubmed |
| pubmed-article:10212298 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10212298 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10212298 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10212298 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10212298 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10212298 | pubmed:pagination | 3384-95 | lld:pubmed |
| pubmed-article:10212298 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10212298 | pubmed:meshHeading | pubmed-meshheading:10212298... | lld:pubmed |
| pubmed-article:10212298 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10212298 | pubmed:articleTitle | Lambert-Eaton antibodies inhibit Ca2+ currents but paradoxically increase exocytosis during stimulus trains in bovine adrenal chromaffin cells. | lld:pubmed |
| pubmed-article:10212298 | pubmed:affiliation | Department of Neurobiology and Anatomy, Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania 19129, USA. | lld:pubmed |
| pubmed-article:10212298 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10212298 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10212298 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10212298 | lld:pubmed |
