| pubmed-article:10208307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10208307 | lifeskim:mentions | umls-concept:C0004238 | lld:lifeskim |
| pubmed-article:10208307 | lifeskim:mentions | umls-concept:C0010055 | lld:lifeskim |
| pubmed-article:10208307 | lifeskim:mentions | umls-concept:C0023517 | lld:lifeskim |
| pubmed-article:10208307 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:10208307 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:10208307 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:10208307 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:10208307 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:10208307 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10208307 | pubmed:dateCreated | 1999-7-9 | lld:pubmed |
| pubmed-article:10208307 | pubmed:abstractText | Atrial fibrillation (AFib) is a frequent complication of coronary artery bypass grafting (CABG). Its cause, however, is unknown. As the adrenergic system is involved in some types of AFib, we hypothesized that a change in guanine nucleotide-binding protein (G protein) expression plays a role in the development of post-CABG AFib. In 28 patients undergoing CABG surgery, the G(s alpha)/G(i alpha) ratio (stimulatory/inhibitory G protein alpha) at the protein (Western blotting) and mRNA (reverse transcription polymerase chain reaction) levels was measured before and after surgery. As a suitable test system allowing multiple analysis mononuclear leukocytes (MNL) were chosen. The perioperative change of the G(s alpha)/G(i alpha) ratio of protein and mRNA was significantly different in patients who subsequently developed AFib (eight patients) and in patients who did not (20 patients; P<0.01 and <0.001, respectively). On average, the protein G(s alpha)/G(i alpha) ratio decreased from 1.79+/-1.13 (mean+/-SD) to 1.32+/-0.69 in patients without AFib (P=0.1, n.s.) whereas a significant increase from 0.86+/-0.44 to 1.62+/-0.65 (P<0.01) was observed in patients subsequently developing AFib. The mRNA G(s alpha)/G(i alpha) ratio decreased significantly from 0.53+/-0.24 to 0.36+/-0.11 in patients without AFib (P<0.01) whereas a significant increase from 0.31+/-0.14 to 0.47+/-0.13 was observed in those who subsequently developed AFib (P<0.05). These results indicate that an increase of the G(s alpha)/G(i alpha) ratio in MNL is associated with AFib after CABG surgery and possibly may be used as a prognostic indicator of this complication. | lld:pubmed |
| pubmed-article:10208307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10208307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10208307 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10208307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10208307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10208307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10208307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10208307 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10208307 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:WisserHH | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:LeePP | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:SchwabMM | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:HellbergKK | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:RatgeDD | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:MörikeKK | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:VolffJ NJN | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:GirayJJ | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:TittelbachVV | lld:pubmed |
| pubmed-article:10208307 | pubmed:author | pubmed-author:LemkePP | lld:pubmed |
| pubmed-article:10208307 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10208307 | pubmed:volume | 359 | lld:pubmed |
| pubmed-article:10208307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10208307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10208307 | pubmed:pagination | 204-11 | lld:pubmed |
| pubmed-article:10208307 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10208307 | pubmed:meshHeading | pubmed-meshheading:10208307... | lld:pubmed |
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| pubmed-article:10208307 | pubmed:meshHeading | pubmed-meshheading:10208307... | lld:pubmed |
| pubmed-article:10208307 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10208307 | pubmed:articleTitle | Atrial fibrillation after coronary artery bypass surgery: association with changes in G protein levels in mononuclear leukocytes. | lld:pubmed |
| pubmed-article:10208307 | pubmed:affiliation | Department of Clinical Pathology, Robert Bosch Krankenhaus, Stuttgart, Germany. | lld:pubmed |
| pubmed-article:10208307 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10208307 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
