| pubmed-article:10198631 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10198631 | lifeskim:mentions | umls-concept:C0086282 | lld:lifeskim |
| pubmed-article:10198631 | lifeskim:mentions | umls-concept:C0013352 | lld:lifeskim |
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| pubmed-article:10198631 | lifeskim:mentions | umls-concept:C0445450 | lld:lifeskim |
| pubmed-article:10198631 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10198631 | pubmed:dateCreated | 1999-4-26 | lld:pubmed |
| pubmed-article:10198631 | pubmed:abstractText | Bcl-2 family members that have only a single Bcl-2 homology domain, BH3, are potent inducers of apoptosis, and some appear to play a critical role in developmentally programmed cell death. We examined the regulation of the proapoptotic activity of the BH3-only protein Bim. In healthy cells, most Bim molecules were bound to LC8 cytoplasmic dynein light chain and thereby sequestered to the microtubule-associated dynein motor complex. Certain apoptotic stimuli disrupted the interaction between LC8 and the dynein motor complex. This freed Bim to translocate together with LC8 to Bcl-2 and to neutralize its antiapoptotic activity. This process did not require caspase activity and therefore constitutes an initiating event in apoptosis signaling. | lld:pubmed |
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| pubmed-article:10198631 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10198631 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10198631 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10198631 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10198631 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:10198631 | pubmed:author | pubmed-author:HuberG AGA | lld:pubmed |
| pubmed-article:10198631 | pubmed:author | pubmed-author:O'ReillyL ALA | lld:pubmed |
| pubmed-article:10198631 | pubmed:author | pubmed-author:KingS MSM | lld:pubmed |
| pubmed-article:10198631 | pubmed:author | pubmed-author:StrasserAA | lld:pubmed |
| pubmed-article:10198631 | pubmed:author | pubmed-author:PuthalakathHH | lld:pubmed |
| pubmed-article:10198631 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10198631 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:10198631 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10198631 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10198631 | pubmed:pagination | 287-96 | lld:pubmed |
| pubmed-article:10198631 | pubmed:dateRevised | 2009-12-11 | lld:pubmed |
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| pubmed-article:10198631 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10198631 | pubmed:articleTitle | The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. | lld:pubmed |
| pubmed-article:10198631 | pubmed:affiliation | Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. | lld:pubmed |
| pubmed-article:10198631 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10198631 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10198631 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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