| pubmed-article:10196218 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10196218 | lifeskim:mentions | umls-concept:C0030520 | lld:lifeskim |
| pubmed-article:10196218 | lifeskim:mentions | umls-concept:C1882714 | lld:lifeskim |
| pubmed-article:10196218 | lifeskim:mentions | umls-concept:C0074785 | lld:lifeskim |
| pubmed-article:10196218 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10196218 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:10196218 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:10196218 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:10196218 | pubmed:dateCreated | 1999-5-17 | lld:pubmed |
| pubmed-article:10196218 | pubmed:abstractText | Parathyroid hormone (PTH) is a potent inhibitor of mammalian renal proximal tubule sodium absorption via suppression of the apical membrane Na/H exchanger (NHE-3). We examined the mechanisms by which PTH inhibits NHE-3 activity by giving an acute intravenous PTH bolus to parathyroidectomized rats. Parathyroidectomy per se increased apical membrane NHE-3 activity and antigen. Acute infusion of PTH caused a time-dependent decrease in NHE-3 activity as early as 30 min. Decrease in NHE-3 activity at 30 and 60 min was accompanied by increased NHE-3 phosphorylation. In contrast to the rapid changes in NHE-3 activity and phosphorylation, decrease in apical membrane NHE-3 antigen was not detectable until 4-12 h after the PTH bolus. The decrease in apical membrane NHE-3 occurred in the absence of changes in total renal cortical NHE-3 antigen. Pretreatment of the animals with the microtubule-disrupting agent colchicine blocked the PTH-induced decrease in apical NHE-3 antigen. We propose that PTH acutely cause a decrease in NHE-3 intrinsic transport activity possibly via a phosphorylation-dependent mechanism followed by a decrease in apical membrane NHE-3 antigen via changes in protein trafficking. | lld:pubmed |
| pubmed-article:10196218 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10196218 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10196218 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10196218 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10196218 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10196218 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10196218 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10196218 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10196218 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10196218 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10196218 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10196218 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10196218 | pubmed:author | pubmed-author:WangHH | lld:pubmed |
| pubmed-article:10196218 | pubmed:author | pubmed-author:CrowderL ALA | lld:pubmed |
| pubmed-article:10196218 | pubmed:author | pubmed-author:GAY | lld:pubmed |
| pubmed-article:10196218 | pubmed:author | pubmed-author:KohM TMT | lld:pubmed |
| pubmed-article:10196218 | pubmed:author | pubmed-author:WiederkehrM... | lld:pubmed |
| pubmed-article:10196218 | pubmed:author | pubmed-author:CollazoRR | lld:pubmed |
| pubmed-article:10196218 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10196218 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:10196218 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10196218 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10196218 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10196218 | pubmed:pagination | 11289-95 | lld:pubmed |
| pubmed-article:10196218 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:meshHeading | pubmed-meshheading:10196218... | lld:pubmed |
| pubmed-article:10196218 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10196218 | pubmed:articleTitle | Dual mechanisms of regulation of Na/H exchanger NHE-3 by parathyroid hormone in rat kidney. | lld:pubmed |
| pubmed-article:10196218 | pubmed:affiliation | Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75225-8856, USA. | lld:pubmed |
| pubmed-article:10196218 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10196218 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10196218 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10196218 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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