| pubmed-article:10195619 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C2608085 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C1824884 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10195619 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10195619 | pubmed:issue | 9-10 | lld:pubmed |
| pubmed-article:10195619 | pubmed:dateCreated | 1999-6-2 | lld:pubmed |
| pubmed-article:10195619 | pubmed:abstractText | DNA molecules complexed with an asialoglycoprotein-polycation conjugate, consisting of asialoorosomucoid (ASOR) coupled to poly-L-lysine, can enter hepatocytes which bear receptors for ASOR. We used this receptor-mediated DNA delivery system to deliver plasmid DNA encoding glycoprotein D (gD) of herpes simplex virus type 1 to ASOR-positive cells. Maximum expression of gD protein was seen at 3 days after injection of this preparation in approximately 13% of cells from BALB/c mice [hepatocytes from mice injected intravenously (i.v.) or peritoneal exudate cells from mice injected intraperitoneally (i.p.)]. In comparison with mice injected with either the plasmid vector alone or the gD-containing plasmid uncomplexed to ASOR, mice immunized with gD-containing plasmid complexed with ASOR-poly-L-lysine induced marked antigen-specific CTL responses. BALB/c mice immunized with gD-DNA developed a T-cell-mediated CTL response against target cells expressing gD and MHC class II glycoproteins, but not against cells expressing only gD and MHC class I molecules. In C3H mice, gD-DNA induced a T-cell-mediated CTL response against target cells expressing gD and class I MHC molecules. Serum anti-gD antibody in low titers were produced in both strains of mice. DNA complexed with ASOR-poly-L-lysine induced CTL responses in mice. | lld:pubmed |
| pubmed-article:10195619 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10195619 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195619 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10195619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10195619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195619 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10195619 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10195619 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:10195619 | pubmed:author | pubmed-author:FinkP SPS | lld:pubmed |
| pubmed-article:10195619 | pubmed:author | pubmed-author:ChiouH CHC | lld:pubmed |
| pubmed-article:10195619 | pubmed:author | pubmed-author:BerberichS... | lld:pubmed |
| pubmed-article:10195619 | pubmed:author | pubmed-author:BigleyN JNJ | lld:pubmed |
| pubmed-article:10195619 | pubmed:author | pubmed-author:CruzP EPE | lld:pubmed |
| pubmed-article:10195619 | pubmed:author | pubmed-author:DrydenT DTD | lld:pubmed |
| pubmed-article:10195619 | pubmed:author | pubmed-author:KhalilP LPL | lld:pubmed |
| pubmed-article:10195619 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10195619 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:10195619 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:10195619 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10195619 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10195619 | pubmed:pagination | 1091-9 | lld:pubmed |
| pubmed-article:10195619 | pubmed:dateRevised | 2006-5-1 | lld:pubmed |
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| pubmed-article:10195619 | pubmed:meshHeading | pubmed-meshheading:10195619... | lld:pubmed |
| pubmed-article:10195619 | pubmed:meshHeading | pubmed-meshheading:10195619... | lld:pubmed |
| pubmed-article:10195619 | pubmed:meshHeading | pubmed-meshheading:10195619... | lld:pubmed |
| pubmed-article:10195619 | pubmed:meshHeading | pubmed-meshheading:10195619... | lld:pubmed |
| pubmed-article:10195619 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10195619 | pubmed:articleTitle | A novel immunization method to induce cytotoxic T-lymphocyte responses (CTL) against plasmid-encoded herpes simplex virus type-1 glycoprotein D. | lld:pubmed |
| pubmed-article:10195619 | pubmed:affiliation | Department of Microbiology, Wright State University, Dayton, OH 45435, USA. | lld:pubmed |
| pubmed-article:10195619 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10195619 | lld:pubmed |
