| pubmed-article:10195419 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10195419 | lifeskim:mentions | umls-concept:C0034788 | lld:lifeskim |
| pubmed-article:10195419 | lifeskim:mentions | umls-concept:C1312062 | lld:lifeskim |
| pubmed-article:10195419 | lifeskim:mentions | umls-concept:C1705297 | lld:lifeskim |
| pubmed-article:10195419 | lifeskim:mentions | umls-concept:C0023158 | lld:lifeskim |
| pubmed-article:10195419 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10195419 | lifeskim:mentions | umls-concept:C1158478 | lld:lifeskim |
| pubmed-article:10195419 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10195419 | lifeskim:mentions | umls-concept:C1705422 | lld:lifeskim |
| pubmed-article:10195419 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10195419 | pubmed:dateCreated | 1999-6-3 | lld:pubmed |
| pubmed-article:10195419 | pubmed:abstractText | The Shc adaptor protein transduces signals from transmembrane receptors to the Ras pathway of cell activation by providing binding sites for the recruitment to the submembrane compartment of the Grb2/Sos G-nucleotide exchange complex. The need for Shc in this process is however unclear since Grb2 can be recruited directly to phosphotyrosine containing membrane receptors through its src-homology-2 domain. Evidence from studies in lymphocytes indicates that Shc is multifunctional and is involved in the integration of independent signals to the Ras pathway. Furthermore, Shc may be a key control point at which signaling can be modulated both by interfering signals and by feedback mechanisms. Here we review recent literature to support these functions for Shc. | lld:pubmed |
| pubmed-article:10195419 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10195419 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195419 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10195419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10195419 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10195419 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10195419 | pubmed:issn | 1431-6730 | lld:pubmed |
| pubmed-article:10195419 | pubmed:author | pubmed-author:TelfordJ LJL | lld:pubmed |
| pubmed-article:10195419 | pubmed:author | pubmed-author:BaldariC TCT | lld:pubmed |
| pubmed-article:10195419 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10195419 | pubmed:volume | 380 | lld:pubmed |
| pubmed-article:10195419 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10195419 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10195419 | pubmed:pagination | 129-34 | lld:pubmed |
| pubmed-article:10195419 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:meshHeading | pubmed-meshheading:10195419... | lld:pubmed |
| pubmed-article:10195419 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10195419 | pubmed:articleTitle | Lymphocyte antigen receptor signal integration and regulation by the SHC adaptor. | lld:pubmed |
| pubmed-article:10195419 | pubmed:affiliation | Department of Evolutionary Biology, University of Siena, Italy. | lld:pubmed |
| pubmed-article:10195419 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10195419 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:10195419 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10195419 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10195419 | lld:pubmed |
