| pubmed-article:10192220 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10192220 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:10192220 | lifeskim:mentions | umls-concept:C1521751 | lld:lifeskim |
| pubmed-article:10192220 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:10192220 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:10192220 | lifeskim:mentions | umls-concept:C0206181 | lld:lifeskim |
| pubmed-article:10192220 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:10192220 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10192220 | pubmed:dateCreated | 1999-5-11 | lld:pubmed |
| pubmed-article:10192220 | pubmed:abstractText | A loss of hippocampal neurons and synapses had been considered a hallmark of normal aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent stereological studies in humans have shown that only a relatively minor neuron loss occurs with aging and that this loss is restricted to specific brain regions, including hippocampal subregions. Here, we investigate these age-related changes in C57BL/6J mice, one of the most commonly used laboratory mouse strains. Twenty-five mice (groups at 2, 14, and 28-31 months of age) were assessed for Morris water-maze performance, and modern stereological techniques were used to estimate total neuron and synaptophysin-positive bouton number in hippocampal subregions at the light microscopic level. Results revealed that performance in the water maze was largely maintained with aging. No age-related decline was observed in number of dentate gyrus granule cells or CA1 pyramidal cells. In addition, no age-related change in number of synaptophysin-positive boutons was observed in the molecular layer of the dentate gyrus or CA1 region of hippocampus. We observed a significant correlation between dentate gyrus synaptophysin-positive bouton number and water-maze performance. These results demonstrate that C57BL/6J mice do not exhibit major age-related deficits in spatial learning or hippocampal structure, providing a baseline for further study of mouse brain aging. | lld:pubmed |
| pubmed-article:10192220 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10192220 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10192220 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10192220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10192220 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10192220 | pubmed:issn | 0197-4580 | lld:pubmed |
| pubmed-article:10192220 | pubmed:author | pubmed-author:LongJ MJM | lld:pubmed |
| pubmed-article:10192220 | pubmed:author | pubmed-author:IngramD KDK | lld:pubmed |
| pubmed-article:10192220 | pubmed:author | pubmed-author:JuckerMM | lld:pubmed |
| pubmed-article:10192220 | pubmed:author | pubmed-author:KurthDD | lld:pubmed |
| pubmed-article:10192220 | pubmed:author | pubmed-author:MoutonP RPR | lld:pubmed |
| pubmed-article:10192220 | pubmed:author | pubmed-author:HengemihleJJ | lld:pubmed |
| pubmed-article:10192220 | pubmed:author | pubmed-author:CalhounM EME | lld:pubmed |
| pubmed-article:10192220 | pubmed:author | pubmed-author:PhinneyA LAL | lld:pubmed |
| pubmed-article:10192220 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10192220 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10192220 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10192220 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10192220 | pubmed:pagination | 599-606 | lld:pubmed |
| pubmed-article:10192220 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10192220 | pubmed:meshHeading | pubmed-meshheading:10192220... | lld:pubmed |
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| pubmed-article:10192220 | pubmed:meshHeading | pubmed-meshheading:10192220... | lld:pubmed |
| pubmed-article:10192220 | pubmed:meshHeading | pubmed-meshheading:10192220... | lld:pubmed |
| pubmed-article:10192220 | pubmed:meshHeading | pubmed-meshheading:10192220... | lld:pubmed |
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| pubmed-article:10192220 | pubmed:meshHeading | pubmed-meshheading:10192220... | lld:pubmed |
| pubmed-article:10192220 | pubmed:articleTitle | Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice. | lld:pubmed |
| pubmed-article:10192220 | pubmed:affiliation | Neuropathology, Institute of Pathology, University of Basel, Switzerland. | lld:pubmed |
| pubmed-article:10192220 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10192220 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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