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| pubmed-article:10187770 | lifeskim:mentions | umls-concept:C2697616 | lld:lifeskim |
| pubmed-article:10187770 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:10187770 | pubmed:dateCreated | 1999-5-3 | lld:pubmed |
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| pubmed-article:10187770 | pubmed:abstractText | We have identified and characterized CIPER, a novel protein containing a caspase recruitment domain (CARD) in its N terminus and a C-terminal region rich in serine and threonine residues. The CARD of CIPER showed striking similarity to E10, a product of the equine herpesvirus-2. CIPER formed homodimers via its CARD and interacted with viral E10 but not with several apoptosis regulators containing CARDs including ARC, RAIDD, RICK, caspase-2, caspase-9, or Apaf-1. Expression of CIPER induced NF-kappaB activation, which was inhibited by dominant-negative NIK and a nonphosphorylable IkappaB-alpha mutant but not by dominant-negative RIP. Mutational analysis revealed that the N-terminal region of CIPER containing the CARD was sufficient and necessary for NF-kappaB-inducing activity. Point mutations in highly conserved residues in the CARD of CIPER disrupted the ability of CIPER to activate NF-kappaB and to form homodimers, indicating that the CARD is essential for NF-kappaB activation and dimerization. We propose that CIPER acts in a NIK-dependent pathway of NF-kappaB activation. | lld:pubmed |
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| pubmed-article:10187770 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10187770 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10187770 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10187770 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10187770 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10187770 | pubmed:author | pubmed-author:ChenSS | lld:pubmed |
| pubmed-article:10187770 | pubmed:author | pubmed-author:MerinoJJ | lld:pubmed |
| pubmed-article:10187770 | pubmed:author | pubmed-author:KosekiTT | lld:pubmed |
| pubmed-article:10187770 | pubmed:author | pubmed-author:InoharaNN | lld:pubmed |
| pubmed-article:10187770 | pubmed:author | pubmed-author:NabelG JGJ | lld:pubmed |
| pubmed-article:10187770 | pubmed:author | pubmed-author:NúñezGG | lld:pubmed |
| pubmed-article:10187770 | pubmed:author | pubmed-author:CarrioRR | lld:pubmed |
| pubmed-article:10187770 | pubmed:author | pubmed-author:HottigerM OMO | lld:pubmed |
| pubmed-article:10187770 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10187770 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:10187770 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10187770 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10187770 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10187770 | pubmed:pagination | 9955-61 | lld:pubmed |
| pubmed-article:10187770 | pubmed:dateRevised | 2008-9-26 | lld:pubmed |
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| pubmed-article:10187770 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10187770 | pubmed:articleTitle | CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. | lld:pubmed |
| pubmed-article:10187770 | pubmed:affiliation | Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | lld:pubmed |
| pubmed-article:10187770 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10187770 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10187770 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10187770 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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