| pubmed-article:10102792 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10102792 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10102792 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:10102792 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:10102792 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:10102792 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10102792 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:10102792 | lifeskim:mentions | umls-concept:C0348016 | lld:lifeskim |
| pubmed-article:10102792 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:10102792 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:10102792 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10102792 | pubmed:dateCreated | 1999-6-2 | lld:pubmed |
| pubmed-article:10102792 | pubmed:abstractText | Recombinant human interleukin-10 (rhIL-10) is a potent and specific immunomodulatory agent which inhibits endotoxin-stimulated pro-inflammatory cytokine production by monocytes, blocks T-lymphocyte activation by antigen presenting cells, and modulates T(H)1/T(H)2 balance in immune responses. In previous clinical trials, rhIL-10 administered to healthy volunteers induced rapid and transient elevations of neutrophil and monocyte counts and reductions of lymphocyte counts in addition to suppression of endotoxin-stimulated whole blood cytokine synthesis. We sought to better characterize the effects of rhIL-10 on immunophenotypically defined subsets of circulating leukocytes that could be relevant to its immunomodulatory effects. Healthy volunteers were given single doses of 10 microg/kg rhIL-10 (n = 8) or equivalent placebo (n = 4) by intravenous injection. Significant changes of circulating leukocytes included transiently increased neutrophils and monocytes with parallel increases of CD33+ and CD14+ cells. Total lymphocytes as well as total CD3+, CD3+/CD4+ and CD3+/CD8+ cells transiently decreased. Mean fluorescence intensity of CD11a (integrin alpha-chain subunit of lymphocyte function antigen-1, LFA-1) on lymphocytes transiently but significantly decreased, suggesting a mechanism for transient alteration of lymphocyte trafficking. In addition, mean fluorescence intensity of HLA-DR (major histocompatibility class II) on CD14+ cells (predominantly monocytes) transiently but significantly decreased, implying a possible alteration of antigen presenting function. Further study will be required to elucidate the immunomodulatory roles and potential clinical significance of these hematologic changes in therapeutic trials of rhIL-10 in patients with chronic inflammatory and autoimmune diseases. | lld:pubmed |
| pubmed-article:10102792 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10102792 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10102792 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10102792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10102792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10102792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10102792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10102792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10102792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10102792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10102792 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10102792 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10102792 | pubmed:issn | 0162-3109 | lld:pubmed |
| pubmed-article:10102792 | pubmed:author | pubmed-author:ClarkeLL | lld:pubmed |
| pubmed-article:10102792 | pubmed:author | pubmed-author:CutlerD LDL | lld:pubmed |
| pubmed-article:10102792 | pubmed:author | pubmed-author:HuhnR DRD | lld:pubmed |
| pubmed-article:10102792 | pubmed:author | pubmed-author:RadwanskiEE | lld:pubmed |
| pubmed-article:10102792 | pubmed:author | pubmed-author:SabaDD | lld:pubmed |
| pubmed-article:10102792 | pubmed:author | pubmed-author:PennlineKK | lld:pubmed |
| pubmed-article:10102792 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10102792 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:10102792 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10102792 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10102792 | pubmed:pagination | 109-17 | lld:pubmed |
| pubmed-article:10102792 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:meshHeading | pubmed-meshheading:10102792... | lld:pubmed |
| pubmed-article:10102792 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10102792 | pubmed:articleTitle | Effects of single intravenous doses of recombinant human interleukin-10 on subsets of circulating leukocytes in humans. | lld:pubmed |
| pubmed-article:10102792 | pubmed:affiliation | Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA. richard.d.huhn@monsanto.com | lld:pubmed |
| pubmed-article:10102792 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10102792 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10102792 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:10102792 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10102792 | lld:pubmed |
