Linked Life Data

10098753

Source:http://linkedlifedata.com/resource/pubmed/id/10098753

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10098753rdf:typepubmed:Citationlld:pubmed
pubmed-article:10098753lifeskim:mentionsumls-concept:C0014852lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C0286983lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C1705784lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C0024204lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C0007137lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C0027627lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C0033684lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C0812444lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C1413246lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:10098753lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:10098753pubmed:issue7-8lld:pubmed
pubmed-article:10098753pubmed:dateCreated1999-4-13lld:pubmed
pubmed-article:10098753pubmed:abstractTextAlthough the mechanisms of action of the transmembrane superfamilies, motility-related protein-1 (MRP-1/CD9) and KAI1/CD82, are not well known, they are reported to suppress the metastasis of several kinds of cancers. The suppression of cell motility by MRP-1/CD9 may cause suppression of the metastasis. As we could not find any reports concerning the expression of MRP-1/CD9 and KAI1/CD82 in oesophageal cancers we investigated their expression in oesophageal specimens. We conducted immunohistochemical staining for MRP1/CD9 against 108 cases of oesophageal squamous cell carcinoma using anti-MRP-1/CD9 monoclonal antibody M31-15, and for KAI1/CD82 against 104 cases using anti-KAI1/CD82 monoclonal antibody C33. To investigate the gradual expression of MRP-1/CD9 and KAI1/CD82, 24 oesophageal dysplasias were immunohistochemically stained using the same method and then investigated. The expression of both MRP-1/CD9 and KAI1/CD82 were positive on the cell membranes of normal oesophageal epithelial cells, but reduced or negative in the cancer cells. Reduced MRP-1/CD9 expressions significantly correlated to tumour depth (P = 0.0009). We found a significantly greater number of reduced or negative expression of MRP-1/CD9 and KAI1/CD82 in lymph node metastatic cases (P = 0.0003 and P= 0.0129, respectively), but not in distant metastatic cases. The 5-year survival rate of MRP-1/CD9-negative and reduced patients was significantly worse than those of positive patients (n = 108, curative cases, RO). Few cases remained KAI1/CD82-positive (9.6%; 10/104) in oesophageal cancer. Twenty (83.3%) and twenty-two (91.7%) cases out of 24 dysplasias were defined as KAI1/CD82-positive and MRP1/CD9-positive, respectively. The decrease in MRP-1/CD9 and KAI1/CD82 expression may facilitate lymph node metastasis in oesophageal squamous cell carcinomas. Knowing the status of the expression of MRP-1/CD9 appears helpful in predicting the prognosis for each patient.lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:languageenglld:pubmed
pubmed-article:10098753pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:citationSubsetIMlld:pubmed
pubmed-article:10098753pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10098753pubmed:statusMEDLINElld:pubmed
pubmed-article:10098753pubmed:monthMarlld:pubmed
pubmed-article:10098753pubmed:issn0007-0920lld:pubmed
pubmed-article:10098753pubmed:authorpubmed-author:ShimadaYYlld:pubmed
pubmed-article:10098753pubmed:authorpubmed-author:ImamuraMMlld:pubmed
pubmed-article:10098753pubmed:authorpubmed-author:UchidaSSlld:pubmed
pubmed-article:10098753pubmed:authorpubmed-author:MiyakeMMlld:pubmed
pubmed-article:10098753pubmed:authorpubmed-author:WatanabeGGlld:pubmed
pubmed-article:10098753pubmed:authorpubmed-author:HoodHHlld:pubmed
pubmed-article:10098753pubmed:authorpubmed-author:LiZ GZGlld:pubmed
pubmed-article:10098753pubmed:issnTypePrintlld:pubmed
pubmed-article:10098753pubmed:volume79lld:pubmed
pubmed-article:10098753pubmed:ownerNLMlld:pubmed
pubmed-article:10098753pubmed:authorsCompleteYlld:pubmed
pubmed-article:10098753pubmed:pagination1168-73lld:pubmed
pubmed-article:10098753pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:meshHeadingpubmed-meshheading:10098753...lld:pubmed
pubmed-article:10098753pubmed:year1999lld:pubmed
pubmed-article:10098753pubmed:articleTitleMotility-related protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma.lld:pubmed
pubmed-article:10098753pubmed:affiliationDepartment of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Japan.lld:pubmed
pubmed-article:10098753pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10098753pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10098753lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10098753lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10098753lld:pubmed