| pubmed-article:10097068 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C1384567 | lld:lifeskim |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C0035339 | lld:lifeskim |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C0040135 | lld:lifeskim |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:10097068 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:10097068 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10097068 | pubmed:dateCreated | 1999-5-12 | lld:pubmed |
| pubmed-article:10097068 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:abstractText | SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor copressor) mediate transcriptional repression of important regulators that are involved in many signaling pathways. SMRT and N-CoR are related proteins that form complexes with mSin3A/B and histone deacetylases to induce local chromatin condensation and transcriptional repression. However, SMRT is substantially smaller than N-CoR, lacking an N-terminal domain of approximately 1,000 aa that are present in N-CoR. Here, we report the identification of SMRT-extended (SMRTe), which contains an N-terminal sequence that shows striking similarity with N-CoR. As in N-CoR, this SMRTe-N-terminal domain also represses basal transcription. We find that SMRTe expression is regulated during cell cycle progression and SMRTe transcripts are present in many embryonic tissues. These data redefine a structurally and functionally more related nuclear receptor corepressor family and suggest an additional role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways. | lld:pubmed |
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| pubmed-article:10097068 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10097068 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10097068 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10097068 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10097068 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10097068 | pubmed:author | pubmed-author:YangMM | lld:pubmed |
| pubmed-article:10097068 | pubmed:author | pubmed-author:LORR | lld:pubmed |
| pubmed-article:10097068 | pubmed:author | pubmed-author:LiHH | lld:pubmed |
| pubmed-article:10097068 | pubmed:author | pubmed-author:ParkE JEJ | lld:pubmed |
| pubmed-article:10097068 | pubmed:author | pubmed-author:ChenJ DJD | lld:pubmed |
| pubmed-article:10097068 | pubmed:author | pubmed-author:SchroenD JDJ | lld:pubmed |
| pubmed-article:10097068 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10097068 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:10097068 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10097068 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10097068 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10097068 | pubmed:pagination | 3519-24 | lld:pubmed |
| pubmed-article:10097068 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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