| pubmed-article:10095978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10095978 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:10095978 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:10095978 | lifeskim:mentions | umls-concept:C0673606 | lld:lifeskim |
| pubmed-article:10095978 | pubmed:issue | 6 Suppl | lld:pubmed |
| pubmed-article:10095978 | pubmed:dateCreated | 1999-6-1 | lld:pubmed |
| pubmed-article:10095978 | pubmed:abstractText | The aims of this paper were to present data on the pharmacokinetics, clearance, bioavailability, and in vivo absorption of etonogestrel (ENG); to present the results of a longitudinal analysis of the plasma concentration-time curves of ENG; and to present the results of a cross-sectional analysis on the association of body weight with serum ENG concentrations. Implanon had an absorption rate of almost 60 micrograms/day after 3 months, which slowly decreased to 30 micrograms/day at the end of 2 years. The bioavailability over this period of time was constant and close to 100%. The clearance remained around 7.5 L/h. With a bioavailability and clearance that remained constant, it was concluded that accumulation of ENG does not occur. After Implanon insertion, serum concentrations increased within 8 h to concentrations associated with ovulation inhibition. Maximum mean serum concentrations (Cmax) amounted to 813 pg/mL and the time (tmax) to reach Cmax was 4 days. After reaching Cmax, ENG serum concentrations declined to about 196 pg/mL at the end of the first year, followed by a slow decline to 156 pg/mL at the end of the third year. After removal of Implanon, serum ENG concentrations declined to levels less than the detection limit of the assay (20 pg/mL) within 1 week. Lower body weight was associated with higher serum ENG concentrations. | lld:pubmed |
| pubmed-article:10095978 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10095978 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10095978 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10095978 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10095978 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10095978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10095978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10095978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10095978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10095978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10095978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10095978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10095978 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10095978 | pubmed:issn | 0010-7824 | lld:pubmed |
| pubmed-article:10095978 | pubmed:author | pubmed-author:HuberJJ | lld:pubmed |
| pubmed-article:10095978 | pubmed:author | pubmed-author:WenzlRR | lld:pubmed |
| pubmed-article:10095978 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10095978 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:10095978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10095978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10095978 | pubmed:pagination | 85S-90S | lld:pubmed |
| pubmed-article:10095978 | pubmed:dateRevised | 2005-3-10 | lld:pubmed |
| pubmed-article:10095978 | pubmed:meshHeading | pubmed-meshheading:10095978... | lld:pubmed |
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| pubmed-article:10095978 | pubmed:meshHeading | pubmed-meshheading:10095978... | lld:pubmed |
| pubmed-article:10095978 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:10095978 | pubmed:articleTitle | Pharmacokinetics of Implanon. An integrated analysis. | lld:pubmed |
| pubmed-article:10095978 | pubmed:affiliation | University of Vienna, General Hospital, Department of Obstetrics and Gynecology, Austria. | lld:pubmed |
| pubmed-article:10095978 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10095978 | pubmed:publicationType | Retracted Publication | lld:pubmed |
| pubmed-article:10095978 | pubmed:publicationType | Meta-Analysis | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10095978 | lld:pubmed |
