| pubmed-article:10094968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10094968 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:10094968 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:10094968 | lifeskim:mentions | umls-concept:C0023911 | lld:lifeskim |
| pubmed-article:10094968 | lifeskim:mentions | umls-concept:C0034897 | lld:lifeskim |
| pubmed-article:10094968 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10094968 | pubmed:dateCreated | 1999-5-20 | lld:pubmed |
| pubmed-article:10094968 | pubmed:abstractText | Chronic infection with the hepatitis C virus (HCV) is the most common reason for liver transplantation. We examined the results of laboratory tests for HCV on a cohort of patients who received a liver transplant between 1990 and 1994 at three large centers. Seven hundred twenty-two recipients and 604 donors were tested for antibody to HCV (anti-HCV) using a second-generation enzyme-linked immunoassay (EIA-2), followed by recombinant immunoblot (RIBA-2) and HCV RNA confirmation by reverse-transcription polymerase chain reaction (RT-PCR) (with genotyping and viral quantification). Diagnosis of posttransplantation infection required detection of serum HCV RNA that could be genotyped by sequencing or was repeatedly positive despite being unsequenceable. Twenty-five percent of transplantation candidates were seropositive for anti-HCV. Approximately 86% of anti-HCV-positive, 93% of RIBA-positive, and 97% of HCV RNA-positive candidates developed infection after transplantation. Pretransplantation HCV RNA was superior to RIBA-2 for predicting posttransplantation infection. Whereas HCV genotype was identified in nearly all candidates and changed little after transplantation, serum viral levels rose markedly after transplantation. Fifteen donors were either anti-HCV- or HCV RNA-positive. Recipients of grafts from donors with HCV RNA all developed infection, whereas infection was not detected in recipients of grafts from donors with anti-HCV but without detectable HCV RNA. The rate of new infection fell significantly (P =.02) after the introduction of EIA-2 screening of blood. Donor and candidate markers for HCV predict posttransplantation infection. | lld:pubmed |
| pubmed-article:10094968 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10094968 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10094968 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10094968 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10094968 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10094968 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10094968 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10094968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10094968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10094968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10094968 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10094968 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:ZettermanR... | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:HoofnagleJ... | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:LakeJ RJR | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:GuJ NJN | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:WeiYY | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:WiesnerR HRH | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:EverhartJ EJE | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:PersingD HDH | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:GermerJ JJJ | lld:pubmed |
| pubmed-article:10094968 | pubmed:author | pubmed-author:CharltonM RMR | lld:pubmed |
| pubmed-article:10094968 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10094968 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:10094968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10094968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10094968 | pubmed:pagination | 1220-6 | lld:pubmed |
| pubmed-article:10094968 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:meshHeading | pubmed-meshheading:10094968... | lld:pubmed |
| pubmed-article:10094968 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10094968 | pubmed:articleTitle | Recurrent and new hepatitis C virus infection after liver transplantation. | lld:pubmed |
| pubmed-article:10094968 | pubmed:affiliation | National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. vyj@cu.nih.gov | lld:pubmed |
| pubmed-article:10094968 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10094968 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10094968 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10094968 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10094968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10094968 | lld:pubmed |
