pubmed-article:10090953 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10090953 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
pubmed-article:10090953 | lifeskim:mentions | umls-concept:C0021013 | lld:lifeskim |
pubmed-article:10090953 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
pubmed-article:10090953 | lifeskim:mentions | umls-concept:C0439859 | lld:lifeskim |
pubmed-article:10090953 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
pubmed-article:10090953 | lifeskim:mentions | umls-concept:C0015730 | lld:lifeskim |
pubmed-article:10090953 | lifeskim:mentions | umls-concept:C0242602 | lld:lifeskim |
pubmed-article:10090953 | pubmed:issue | 7 | lld:pubmed |
pubmed-article:10090953 | pubmed:dateCreated | 1999-4-19 | lld:pubmed |
pubmed-article:10090953 | pubmed:abstractText | The idiotype (Id) determinant on the multiple myeloma (MM) protein can be regarded as a tumor-specific marker. Immunotherapy directed at the MM Id may stem the progression of this disease. We report here on the first 12 MM patients treated at our institution with high-dose therapy and peripheral blood stem cell transplantation (PBSCT) followed by Id immunizations. MM patients received PBSCT to eradicate the majority of the disease. PBSCT produced a complete response in 2 patients, a partial response in 9 patients and stable disease in 1 patient. Three to 7 months after high-dose therapy, patients received a series of monthly immunizations that consisted of two intravenous infusions of Id-pulsed autologous dendritic cells (DC) followed by five subcutaneous boosts of Id/keyhole limpet hemocyanin (KLH) administered with adjuvant. Between 1 and 11 x 10(6) DC were obtained by leukapheresis in all patients even after PBSCT. The administration of Id-pulsed DC and Id/KLH vaccines were well tolerated with patients experiencing only minor and transient side effects. Two of 12 patients developed an Id-specific, cellular proliferative immune response and one of three patients studied developed a transient but Id-specific cytotoxic T-cell (CTL) response. Eleven of the 12 patients generated strong KLH-specific cellular proliferative immune responses showing the patients' immunocompetence at the time of vaccination. The two patients who developed a cellular Id-specific immune response remain in complete remission. Of the 12 treated patients, 9 are currently alive after autologous transplantation with a minimum follow-up of 16 months, 2 patients died because of recurrent MM and 1 patient succumbed to acute leukemia. These studies show that patients make strong anti-KLH responses despite recent high-dose therapy and that DC-based Id vaccination is feasible after PBSCT and can induce Id-specific T-cell responses. Further vaccine development is necessary to increase the proportion of patients that make Id-specific immune responses. The clinical benefits of Id vaccination in MM remain to be determined. | lld:pubmed |
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pubmed-article:10090953 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10090953 | pubmed:language | eng | lld:pubmed |
pubmed-article:10090953 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10090953 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:10090953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10090953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10090953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:10090953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10090953 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10090953 | pubmed:month | Apr | lld:pubmed |
pubmed-article:10090953 | pubmed:issn | 0006-4971 | lld:pubmed |
pubmed-article:10090953 | pubmed:author | pubmed-author:LissEE | lld:pubmed |
pubmed-article:10090953 | pubmed:author | pubmed-author:LevyRR | lld:pubmed |
pubmed-article:10090953 | pubmed:author | pubmed-author:BlumeK GKG | lld:pubmed |
pubmed-article:10090953 | pubmed:author | pubmed-author:EnglemanE GEG | lld:pubmed |
pubmed-article:10090953 | pubmed:author | pubmed-author:BenikeC JCJ | lld:pubmed |
pubmed-article:10090953 | pubmed:author | pubmed-author:OkadaC YCY | lld:pubmed |
pubmed-article:10090953 | pubmed:author | pubmed-author:Stockerl-Gold... | lld:pubmed |
pubmed-article:10090953 | pubmed:author | pubmed-author:ReichardtV... | lld:pubmed |
pubmed-article:10090953 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10090953 | pubmed:day | 1 | lld:pubmed |
pubmed-article:10090953 | pubmed:volume | 93 | lld:pubmed |
pubmed-article:10090953 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10090953 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10090953 | pubmed:pagination | 2411-9 | lld:pubmed |
pubmed-article:10090953 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:10090953 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10090953 | pubmed:articleTitle | Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma--a feasibility study. | lld:pubmed |
pubmed-article:10090953 | pubmed:affiliation | Division of Oncology, Stanford Blood Center, Stanford University Medical Center, Stanford, CA, USA. | lld:pubmed |
pubmed-article:10090953 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10090953 | pubmed:publicationType | Clinical Trial | lld:pubmed |
pubmed-article:10090953 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:10090953 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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