| pubmed-article:10087086 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10087086 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10087086 | lifeskim:mentions | umls-concept:C0033147 | lld:lifeskim |
| pubmed-article:10087086 | lifeskim:mentions | umls-concept:C0228405 | lld:lifeskim |
| pubmed-article:10087086 | lifeskim:mentions | umls-concept:C1521827 | lld:lifeskim |
| pubmed-article:10087086 | lifeskim:mentions | umls-concept:C1705848 | lld:lifeskim |
| pubmed-article:10087086 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10087086 | pubmed:dateCreated | 1999-4-13 | lld:pubmed |
| pubmed-article:10087086 | pubmed:abstractText | We investigated how the brain switches between the preparation of a movement where a stimulus is the target of the movement, and a movement where a stimulus serves as a landmark for an instructed movement elsewhere. Monkeys were trained on a pro-/anti-saccade paradigm in which they either had to generate a pro-saccade toward a visual stimulus or an anti-saccade away from the stimulus to its mirror position, depending on the color of an initial fixation point. Neural activity was recorded in the superior colliculus (SC), a structure that is known to be involved in the generation of fast saccades, to determine whether it was also involved in the generation of anti-saccades. On anti-saccade trials, fixation during the instruction period was associated with an increased activity of collicular fixation-related neurons and a decreased activity of saccade-related neurons. Stimulus-related and saccade-related activity was reduced on anti-saccade trials. Our results demonstrate that the anti-saccade task involves (and may require) the attenuation of preparatory and stimulus-related activity in the SC to avoid unwanted pro-saccades. Because the attenuated pre-saccade activity that we found in the SC may be insufficient by itself to elicit correct anti-saccades, additional movement signals from other brain areas are presumably required. | lld:pubmed |
| pubmed-article:10087086 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10087086 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10087086 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10087086 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10087086 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10087086 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:10087086 | pubmed:author | pubmed-author:KleinR MRM | lld:pubmed |
| pubmed-article:10087086 | pubmed:author | pubmed-author:MunozD PDP | lld:pubmed |
| pubmed-article:10087086 | pubmed:author | pubmed-author:DorrisM CMC | lld:pubmed |
| pubmed-article:10087086 | pubmed:author | pubmed-author:EverlingSS | lld:pubmed |
| pubmed-article:10087086 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10087086 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10087086 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10087086 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10087086 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10087086 | pubmed:pagination | 2740-54 | lld:pubmed |
| pubmed-article:10087086 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:10087086 | pubmed:meshHeading | pubmed-meshheading:10087086... | lld:pubmed |
| pubmed-article:10087086 | pubmed:meshHeading | pubmed-meshheading:10087086... | lld:pubmed |
| pubmed-article:10087086 | pubmed:meshHeading | pubmed-meshheading:10087086... | lld:pubmed |
| pubmed-article:10087086 | pubmed:meshHeading | pubmed-meshheading:10087086... | lld:pubmed |
| pubmed-article:10087086 | pubmed:meshHeading | pubmed-meshheading:10087086... | lld:pubmed |
| pubmed-article:10087086 | pubmed:meshHeading | pubmed-meshheading:10087086... | lld:pubmed |
| pubmed-article:10087086 | pubmed:meshHeading | pubmed-meshheading:10087086... | lld:pubmed |
| pubmed-article:10087086 | pubmed:meshHeading | pubmed-meshheading:10087086... | lld:pubmed |
| pubmed-article:10087086 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10087086 | pubmed:articleTitle | Role of primate superior colliculus in preparation and execution of anti-saccades and pro-saccades. | lld:pubmed |
| pubmed-article:10087086 | pubmed:affiliation | Medical Research Council Group in Sensory-Motor Neuroscience, Department of Physiology, Queen's University, Kingston, Ontario, Canada, K7L 3N6. | lld:pubmed |
| pubmed-article:10087086 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10087086 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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