| pubmed-article:10085034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10085034 | lifeskim:mentions | umls-concept:C0023860 | lld:lifeskim |
| pubmed-article:10085034 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:10085034 | lifeskim:mentions | umls-concept:C1704264 | lld:lifeskim |
| pubmed-article:10085034 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10085034 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10085034 | pubmed:dateCreated | 1999-4-26 | lld:pubmed |
| pubmed-article:10085034 | pubmed:abstractText | Interleukin-1 receptor antagonist (IL-1ra) is a naturally occurring cytokine whose only known function is the inhibition of interleukin-1 (IL-1). Using a reverse genetic approach in mice, we previously showed that increasing IL-1ra gene dosage leads to reduced survival of a primary listerial infection. In this study, we characterize further the role of endogenously produced IL-1ra and, by inference, IL-1 in murine listeriosis. IL-1ra overexpression inhibits, but does not eliminate, primary immune responses, reducing survival and increasing bacterial loads in the target organs. We demonstrate that IL-1ra functions in the innate immune response to regulate the peak leukocyte levels in the blood, the accumulation of leukocytes at sites of infection, and the activation of macrophages during a primary infection. Reduced macrophage class II major histocompatibility complex expression was observed despite increased gamma interferon (IFN-gamma) levels, suggesting that IL-1 activity is essential along with IFN-gamma for macrophage activation in vivo. We also show that IL-1ra plays a more limited role during secondary listeriosis, blunting the strength of the delayed-type hypersensitivity response to listerial antigen while not significantly altering cellular immunity to a second infectious challenge. When these results are compared to those for other mutant mice, IL-1ra appears to be unique among the cytokines studied to date in its regulation of leukocyte migration during primary listeriosis. | lld:pubmed |
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| pubmed-article:10085034 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10085034 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10085034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10085034 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10085034 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:10085034 | pubmed:author | pubmed-author:HirschEE | lld:pubmed |
| pubmed-article:10085034 | pubmed:author | pubmed-author:HirshDD | lld:pubmed |
| pubmed-article:10085034 | pubmed:author | pubmed-author:IrikuraV MVM | lld:pubmed |
| pubmed-article:10085034 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10085034 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:10085034 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10085034 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10085034 | pubmed:pagination | 1901-9 | lld:pubmed |
| pubmed-article:10085034 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10085034 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10085034 | pubmed:articleTitle | Effects of interleukin-1 receptor antagonist overexpression on infection by Listeria monocytogenes. | lld:pubmed |
| pubmed-article:10085034 | pubmed:affiliation | Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. | lld:pubmed |
| pubmed-article:10085034 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10085034 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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