| pubmed-article:10080531 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10080531 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:10080531 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:10080531 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:10080531 | lifeskim:mentions | umls-concept:C0134835 | lld:lifeskim |
| pubmed-article:10080531 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:10080531 | lifeskim:mentions | umls-concept:C0205284 | lld:lifeskim |
| pubmed-article:10080531 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10080531 | pubmed:dateCreated | 1999-4-1 | lld:pubmed |
| pubmed-article:10080531 | pubmed:abstractText | During an acute inflammatory response, endothelial P-selectin (CD62P) can mediate the initial capture of neutrophils from the free flowing bloodstream. P-selectin is stored in secretory granules (Weibel-Palade bodies) and is rapidly expressed on the endothelial surface after stimulation with histamine or thrombin. Because neutrophil transmigration occurs preferentially at endothelial borders, we wished to determine whether P-selectin-dependent neutrophil capture (adhesion) occurs at endothelial cell borders. Under static or hydrodynamic flow (2 dyn/cm2) conditions, histamine (10(-4) M) or thrombin (0.2 U/mL) treatment induced preferential (> or = 75%) neutrophil adhesion to the cell borders of endothelial monolayers. Blocking antibody studies established that neutrophil adhesion was completely P-selectin dependent. P-selectin surface expression increased significantly after histamine treatment and P-selectin immunostaining was concentrated along endothelial borders. We conclude that preferential P-selectin expression along endothelial borders may be an important mechanism for targeting neutrophil migration at endothelial borders. | lld:pubmed |
| pubmed-article:10080531 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10080531 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10080531 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10080531 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10080531 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10080531 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10080531 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10080531 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10080531 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10080531 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:10080531 | pubmed:author | pubmed-author:EntmanM LML | lld:pubmed |
| pubmed-article:10080531 | pubmed:author | pubmed-author:AbeYY | lld:pubmed |
| pubmed-article:10080531 | pubmed:author | pubmed-author:SmithC WCW | lld:pubmed |
| pubmed-article:10080531 | pubmed:author | pubmed-author:BurnsA RAR | lld:pubmed |
| pubmed-article:10080531 | pubmed:author | pubmed-author:WalkerD CDC | lld:pubmed |
| pubmed-article:10080531 | pubmed:author | pubmed-author:BowdenR ARA | lld:pubmed |
| pubmed-article:10080531 | pubmed:author | pubmed-author:SimonS ISI | lld:pubmed |
| pubmed-article:10080531 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10080531 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:10080531 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10080531 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10080531 | pubmed:pagination | 299-306 | lld:pubmed |
| pubmed-article:10080531 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10080531 | pubmed:meshHeading | pubmed-meshheading:10080531... | lld:pubmed |
| pubmed-article:10080531 | pubmed:meshHeading | pubmed-meshheading:10080531... | lld:pubmed |
| pubmed-article:10080531 | pubmed:meshHeading | pubmed-meshheading:10080531... | lld:pubmed |
| pubmed-article:10080531 | pubmed:meshHeading | pubmed-meshheading:10080531... | lld:pubmed |
| pubmed-article:10080531 | pubmed:meshHeading | pubmed-meshheading:10080531... | lld:pubmed |
| pubmed-article:10080531 | pubmed:meshHeading | pubmed-meshheading:10080531... | lld:pubmed |
| pubmed-article:10080531 | pubmed:meshHeading | pubmed-meshheading:10080531... | lld:pubmed |
| pubmed-article:10080531 | pubmed:meshHeading | pubmed-meshheading:10080531... | lld:pubmed |
| pubmed-article:10080531 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10080531 | pubmed:articleTitle | P-selectin mediates neutrophil adhesion to endothelial cell borders. | lld:pubmed |
| pubmed-article:10080531 | pubmed:affiliation | Section of Cardiovascular Sciences, Baylor College of Medicine, Houston, Texas 77030, USA. aburns@bcm.tmc.edu | lld:pubmed |
| pubmed-article:10080531 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10080531 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10080531 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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