| pubmed-article:10079108 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10079108 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10079108 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:10079108 | lifeskim:mentions | umls-concept:C0282552 | lld:lifeskim |
| pubmed-article:10079108 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:10079108 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10079108 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10079108 | pubmed:dateCreated | 1999-4-2 | lld:pubmed |
| pubmed-article:10079108 | pubmed:abstractText | The potential roles of adhesion molecules in the expansion of T cell-mediated immune responses in the periphery were examined using DNA immunogen constructs as model antigens. We coimmunized cDNA expression cassettes encoding the adhesion molecules intracellular adhesion molecule-1 (ICAM-1), lymphocyte function associated-3 (LFA-3), and vascular cell adhesion molecule-1 (VCAM-1) along with DNA immunogens, and we analyzed the resulting antigen-specific immune responses. We observed that antigen-specific T-cell responses can be enhanced by the coexpression of DNA immunogen and adhesion molecules ICAM-1 and LFA-3. Coexpression of ICAM-1 or LFA-3 molecules along with DNA immunogens resulted in a significant enhancement of T-helper cell proliferative responses. In addition, coimmunization with pCICAM-1 (and more moderately with pCLFA-3) resulted in a dramatic enhancement of CD8-restricted cytotoxic T-lymphocyte responses. Although VCAM-1 and ICAM-1 are similar in size, VCAM-1 coimmunization did not have any measurable effect on cell-mediated responses. These results suggest that ICAM-1 and LFA-3 provide direct T-cell costimulation. These observations are further supported by the finding that coinjection with ICAM-1 dramatically enhanced the level of interferon-gamma (IFN-gamma) and beta-chemokines macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and regulated on activation normal T-cell expression and secreted (RANTES) produced by stimulated T cells. Through comparative studies, we observed that ICAM-1/LFA-1 T-cell costimulatory pathways are independent of CD86/CD28 pathways and that they may synergistically expand T-cell responses in vivo. | lld:pubmed |
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| pubmed-article:10079108 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10079108 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10079108 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10079108 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10079108 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10079108 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10079108 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:LeeD JDJ | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:LEEM JMJJr | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:WeinerD BDB | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:KimJ JJJ | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:DanaMM | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:MorrisonLL | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:TsaiAA | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:AgadjanyanM... | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:ChalianA AAA | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:NottinghamL... | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:CunningD MDM | lld:pubmed |
| pubmed-article:10079108 | pubmed:author | pubmed-author:DentchevTT | lld:pubmed |
| pubmed-article:10079108 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10079108 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:10079108 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10079108 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10079108 | pubmed:pagination | 869-77 | lld:pubmed |
| pubmed-article:10079108 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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