| pubmed-article:10075977 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10075977 | lifeskim:mentions | umls-concept:C0125090 | lld:lifeskim |
| pubmed-article:10075977 | lifeskim:mentions | umls-concept:C1136143 | lld:lifeskim |
| pubmed-article:10075977 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10075977 | lifeskim:mentions | umls-concept:C2347946 | lld:lifeskim |
| pubmed-article:10075977 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10075977 | pubmed:dateCreated | 1999-5-27 | lld:pubmed |
| pubmed-article:10075977 | pubmed:abstractText | The velocity of rolling leukocytes is thought to be determined by the expression of adhesion molecules and the prevailing wall shear stress. Here, we investigate whether rapid cleavage of L-selectin may be an additional physiologic regulatory parameter of leukocyte rolling. A unique protease in the membrane of leukocytes cleaves L-selectin after activation, resulting in L-selectin shedding. The hydroxamic acid-based metalloprotease inhibitor KD-IX-73-4 completely prevented L-selectin shedding in vitro and significantly decreased the rolling velocity of leukocytes in untreated wild-type C57BL/6 mice from 55 to 35 micrometer/seconds in vivo. When E-selectin was expressed on the endothelium (tumor necrosis factor [TNF]-alpha treatment 2.5-3 h before the experiment), rolling velocity was 4 micrometer/seconds and did not change after the application of KD-IX-73-4. However, KD-IX-73-4 decreased mean rolling velocity by 29% from 23 to 16 micrometer/seconds in E-selectin-deficient mice treated with TNF-alpha. The reduction of velocity caused by KD-IX-73-4 was immediate (<5 s) after injection of KD-IX-73-4 as shown by a novel method using a local catheter. These results establish a role for L-selectin shedding in regulating leukocyte rolling velocity in vivo. | lld:pubmed |
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| pubmed-article:10075977 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10075977 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10075977 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10075977 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10075977 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10075977 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:10075977 | pubmed:author | pubmed-author:LeyKK | lld:pubmed |
| pubmed-article:10075977 | pubmed:author | pubmed-author:Hafezi-Moghad... | lld:pubmed |
| pubmed-article:10075977 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10075977 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10075977 | pubmed:volume | 189 | lld:pubmed |
| pubmed-article:10075977 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10075977 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10075977 | pubmed:pagination | 939-48 | lld:pubmed |
| pubmed-article:10075977 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10075977 | pubmed:meshHeading | pubmed-meshheading:10075977... | lld:pubmed |
| pubmed-article:10075977 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10075977 | pubmed:articleTitle | Relevance of L-selectin shedding for leukocyte rolling in vivo. | lld:pubmed |
| pubmed-article:10075977 | pubmed:affiliation | Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA. | lld:pubmed |
| pubmed-article:10075977 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10075977 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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