| pubmed-article:10074486 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C0205463 | lld:lifeskim |
| pubmed-article:10074486 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:10074486 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10074486 | pubmed:dateCreated | 1999-3-31 | lld:pubmed |
| pubmed-article:10074486 | pubmed:abstractText | Chronic hypoxia induces polycythemia, pulmonary hypertension, right ventricular hypertrophy, and weight loss. Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to hypoxia, including erythropoietin, vascular endothelial growth factor, and glycolytic enzymes. Expression of the HIF-1alpha subunit increases exponentially as O2 concentration is decreased. Hif1a-/- mouse embryos with complete deficiency of HIF-1alpha due to homozygosity for a null allele at the Hif1a locus die at midgestation, with multiple cardiovascular malformations and mesenchymal cell death. Hif1a+/- heterozygotes develop normally and are indistinguishable from Hif1a+/+ wild-type littermates when maintained under normoxic conditions. In this study, the physiological responses of Hif1a+/- and Hif1a+/+ mice exposed to 10% O2 for one to six weeks were analyzed. Hif1a+/- mice demonstrated significantly delayed development of polycythemia, right ventricular hypertrophy, pulmonary hypertension, and pulmonary vascular remodeling and significantly greater weight loss compared with wild-type littermates. These results indicate that partial HIF-1alpha deficiency has significant effects on multiple systemic responses to chronic hypoxia. | lld:pubmed |
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| pubmed-article:10074486 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10074486 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10074486 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10074486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10074486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10074486 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10074486 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10074486 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:ShawJ MJM | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:McWilliamsRR | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:SylvesterJ... | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:SudVV | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:SemenzaG LGL | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:YuA YAY | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:WienerC MCM | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:BeatyTT | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:HusoD LDL | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:IyerN VNV | lld:pubmed |
| pubmed-article:10074486 | pubmed:author | pubmed-author:ShimodaL ALA | lld:pubmed |
| pubmed-article:10074486 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10074486 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:10074486 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10074486 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10074486 | pubmed:pagination | 691-6 | lld:pubmed |
| pubmed-article:10074486 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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