| pubmed-article:10068591 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10068591 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10068591 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:10068591 | lifeskim:mentions | umls-concept:C0041327 | lld:lifeskim |
| pubmed-article:10068591 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10068591 | pubmed:dateCreated | 1999-4-21 | lld:pubmed |
| pubmed-article:10068591 | pubmed:abstractText | Mycobacterium tuberculosis (MTB)-induced T cell responses are depressed in peripheral blood mononuclear cells of persons with newly diagnosed pulmonary tuberculosis (TB), and levels of interferon (IFN)-gamma remain low even after completion of antituberculous therapy. Loss of MTB-reactive T cells through apoptotic mechanisms could account for this prolonged T cell hyporesponsiveness. T cell apoptosis was studied in TB patients and healthy control subjects. Both spontaneous and MTB-induced apoptosis (in CD4 and non-CD4 T cells) from TB patients was increased when compared with healthy control subjects, whereas coculture with control antigen (candida) had no effect on T cell apoptosis in either group of study subjects. An inverse correlation existed between increased MTB-induced T cell apoptosis and IFN-gamma and interleukin (IL)-2 immunoreactivities. Successful antituberculous chemotherapy resulted in a 50% reduction in both spontaneous and MTB-induced apoptosis, which coincided with 3- and 8-fold increases in levels of MTB-stimulated IL-2 and IFN-gamma, respectively. These data indicate that apoptotic pathways are operant during active MTB infection and may contribute to deletion of MTB-reactive T cells and the immunopathogenesis of this disease. | lld:pubmed |
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| pubmed-article:10068591 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10068591 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10068591 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10068591 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10068591 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10068591 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10068591 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10068591 | pubmed:author | pubmed-author:JohnsonJ LJL | lld:pubmed |
| pubmed-article:10068591 | pubmed:author | pubmed-author:EllnerJ JJJ | lld:pubmed |
| pubmed-article:10068591 | pubmed:author | pubmed-author:PetersPP | lld:pubmed |
| pubmed-article:10068591 | pubmed:author | pubmed-author:HirschC SCS | lld:pubmed |
| pubmed-article:10068591 | pubmed:author | pubmed-author:VanhamGG | lld:pubmed |
| pubmed-article:10068591 | pubmed:author | pubmed-author:ToossiZZ | lld:pubmed |
| pubmed-article:10068591 | pubmed:author | pubmed-author:OkweraAA | lld:pubmed |
| pubmed-article:10068591 | pubmed:author | pubmed-author:MugerwaRR | lld:pubmed |
| pubmed-article:10068591 | pubmed:author | pubmed-author:MugyenyiPP | lld:pubmed |
| pubmed-article:10068591 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10068591 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:10068591 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10068591 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10068591 | pubmed:pagination | 945-53 | lld:pubmed |
| pubmed-article:10068591 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10068591 | pubmed:meshHeading | pubmed-meshheading:10068591... | lld:pubmed |
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| pubmed-article:10068591 | pubmed:meshHeading | pubmed-meshheading:10068591... | lld:pubmed |
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| pubmed-article:10068591 | pubmed:meshHeading | pubmed-meshheading:10068591... | lld:pubmed |
| pubmed-article:10068591 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10068591 | pubmed:articleTitle | Apoptosis and T cell hyporesponsiveness in pulmonary tuberculosis. | lld:pubmed |
| pubmed-article:10068591 | pubmed:affiliation | Department of Medicine, Division of Infectious Diseases, Case Western Reserve University, Cleveland, OH 44106-4984, USA. cxh40@po.cwru.edu | lld:pubmed |
| pubmed-article:10068591 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10068591 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10068591 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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