| pubmed-article:10064589 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C0521449 | lld:lifeskim |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C0288472 | lld:lifeskim |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C0249197 | lld:lifeskim |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C1420626 | lld:lifeskim |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10064589 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:10064589 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10064589 | pubmed:dateCreated | 1999-4-29 | lld:pubmed |
| pubmed-article:10064589 | pubmed:abstractText | p21(Cip1/WAF1) inhibits cell-cycle progression by binding to G1 cyclin/CDK complexes and proliferating cell nuclear antigen (PCNA) through its N- and C-terminal domains, respectively. The cell-cycle inhibitory activity of p21(Cip1/WAF1) is correlated with its nuclear localization. Here, we report a novel cytoplasmic localization of p21(Cip1/WAF1) in peripheral blood monocytes (PBMs) and in U937 cells undergoing monocytic differentiation by in vitro treatment with vitamin D3 or ectopic expression of p21(Cip1/WAF1), and analyze the biological consequences of this cytoplasmic expression. U937 cells which exhibit nuclear p21(Cip1/WAF1) demonstrated G1 cell-cycle arrest and subsequently differentiated into monocytes. The latter event was associated with a cytoplasmic expression of nuclear p21(Cip1/WAF1), concomitantly with a resistance to various apoptogenic stimuli. Biochemical analysis showed that cytoplasmic p21(Cip1/WAF1) forms a complex with the apoptosis signal-regulating kinase 1 (ASK1) and inhibits stress-activated MAP kinase cascade. Expression of a deletion mutant of p21(Cip1/WAF1) lacking the nuclear localization signal (DeltaNLS-p21) did not induce cell cycle arrest nor monocytic differentiation, but led to an apoptosis-resistant phenotype, mediated by binding to and inhibition of the stress-activated ASK1 activity. Thus, cytoplasmic p21(Cip1/WAF1) itself acted as an inhibitor of apoptosis. Our findings highlight the different functional roles of p21(Cip1/WAF1), which are determined by its intracellular distribution and are dependent on the stage of differentiation. | lld:pubmed |
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| pubmed-article:10064589 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10064589 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064589 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10064589 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10064589 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:10064589 | pubmed:author | pubmed-author:YamadaTT | lld:pubmed |
| pubmed-article:10064589 | pubmed:author | pubmed-author:MizutaniSS | lld:pubmed |
| pubmed-article:10064589 | pubmed:author | pubmed-author:AsadaMM | lld:pubmed |
| pubmed-article:10064589 | pubmed:author | pubmed-author:IchijoHH | lld:pubmed |
| pubmed-article:10064589 | pubmed:author | pubmed-author:DeliaDD | lld:pubmed |
| pubmed-article:10064589 | pubmed:author | pubmed-author:MiyazonoKK | lld:pubmed |
| pubmed-article:10064589 | pubmed:author | pubmed-author:FukumuroKK | lld:pubmed |
| pubmed-article:10064589 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10064589 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10064589 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10064589 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10064589 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10064589 | pubmed:pagination | 1223-34 | lld:pubmed |
| pubmed-article:10064589 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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