| pubmed-article:10064094 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C0935929 | lld:lifeskim |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C1999177 | lld:lifeskim |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C1707797 | lld:lifeskim |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C1637379 | lld:lifeskim |
| pubmed-article:10064094 | lifeskim:mentions | umls-concept:C0675074 | lld:lifeskim |
| pubmed-article:10064094 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10064094 | pubmed:dateCreated | 1999-4-22 | lld:pubmed |
| pubmed-article:10064094 | pubmed:abstractText | A newly synthesized antidiabetic agent, JTT-501 is an isoxazolidinedione rather than a thiazolidinedione. An oral dose of JTT-501 (100 mg x kg(-1) x day(-1)) given to 12-week-old male Zucker fatty rats for 7 days led to the amelioration of both hyperinsulinaemia (40% of non-treated) and hypertriglyceridaemia (23% of non-treated) as well as a 2.4-fold increased insulin sensitivity as determined by a euglycaemic insulin clamp. In our study, we further evaluated the acute effect of JTT-501 on both the glucose infusion rates (GIR) and insulin signalling in skeletal muscle. Male Sprague-Dawley (SD) rats aged 10 weeks were injected intravenously with JTT-501 (5 mg/kg) and then a euglycaemic insulin clamp was initiated and glucose infusion rates monitored for 150 min. We found that this treatment increased the glucose infusion rate by 33% during the last 30 min in SD rats. After the clamp had been initiated for 30 min, the insulin-stimulated phosphatidylinositol 3-kinase (PI3-kinase) activities co-immunoprecipitated with insulin receptor substrate 1 (IRS-1) were also enhanced, resulting in increased glycogen synthase activities in the soleus muscles. Treatment with JTT-501 also enhanced the phosphorylation of insulin receptors and insulin receptor-substrate 1 rapidly as well as the phosphatidylinositol 3-kinase activities, which were stimulated by a bolus injection of insulin. Similarly, JTT-501 stimulated the glucose infusion rate by 30% and enhanced insulin signalling in Zucker fatty rats. In conclusion, a newly developed isoxazolidinedione, JTT-501, rapidly potentiates the insulin sensitivity of skeletal muscle by enhancing insulin signalling and could be useful for the treatment of insulin-resistant diabetic subjects. | lld:pubmed |
| pubmed-article:10064094 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10064094 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064094 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10064094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10064094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064094 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10064094 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10064094 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:ShibataTT | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:KojimaHH | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:HidakaHH | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:FujitaTT | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:YasudaHH | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:ObataTT | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:VIGPP | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:KashiwagiAA | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:KikkawaRR | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:NishioYY | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:HanedaMM | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:MaegawaHH | lld:pubmed |
| pubmed-article:10064094 | pubmed:author | pubmed-author:MorinoKK | lld:pubmed |
| pubmed-article:10064094 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10064094 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:10064094 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10064094 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10064094 | pubmed:pagination | 151-9 | lld:pubmed |
| pubmed-article:10064094 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:10064094 | pubmed:meshHeading | pubmed-meshheading:10064094... | lld:pubmed |
| pubmed-article:10064094 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10064094 | pubmed:articleTitle | A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle. | lld:pubmed |
| pubmed-article:10064094 | pubmed:affiliation | Third Department of Medicine, Shiga University of Medical Science, Seta, Japan. | lld:pubmed |
| pubmed-article:10064094 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10064094 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10064094 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10064094 | lld:pubmed |
