Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10051443rdf:typepubmed:Citationlld:pubmed
pubmed-article:10051443lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:10051443lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:10051443lifeskim:mentionsumls-concept:C0206131lld:lifeskim
pubmed-article:10051443lifeskim:mentionsumls-concept:C1622537lld:lifeskim
pubmed-article:10051443lifeskim:mentionsumls-concept:C1879748lld:lifeskim
pubmed-article:10051443lifeskim:mentionsumls-concept:C1706853lld:lifeskim
pubmed-article:10051443pubmed:dateCreated1999-5-4lld:pubmed
pubmed-article:10051443pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:abstractTextSNARE proteins are required for vesicle docking and fusion in eukaryotic cells in processes as diverse as homotypic membrane fusion and synaptic vesicle exocytosis [SNARE stands for SNAP receptor, where SNAP is soluble NSF attachment protein]. The SNARE proteins syntaxin 4 and vesicle-associated membrane protein (VAMP) 2/3 also participate in the insulin-stimulated translocation of GLUT4 from intracellular vesicles to the plasma membrane in adipose cells. We now report the molecular cloning and characterization of rat SNAP-23, a ubiquitously expressed homologue of the essential neuronal SNARE protein SNAP-25 (synaptosomal-associated protein of 25 kDa). Rat SNAP-23 is 86% and 98% identical respectively to human and mouse SNAP-23. Southern blot analysis reveals that the rat, mouse and human SNAP-23 genes encode species-specific isoforms of the same protein. Co-immunoprecipitation of syntaxin 4 and SNAP-23 shows association of these two proteins in rat adipose cell plasma membranes, and insulin stimulation does not alter the SNAP-23/syntaxin 4 complex. In addition, we demonstrate for the first time the participation of SNAP-23, along with syntaxin 4 and VAMP2/3, in the formation of 20S SNARE complexes prepared using rat adipose cell membranes and recombinant alpha-SNAP and NSF proteins. The stoichiometry of the SNARE complexes formed is essentially identical using membranes from either unstimulated or insulin-stimulated adipose cells. These data demonstrate that rat SNAP-23 associates with syntaxin 4 before insulin stimulation and is present in the SNARE complexes known to mediate the translocation of GLUT4 from intracellular vesicles to the plasma membrane of rat adipose cells.lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:languageenglld:pubmed
pubmed-article:10051443pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:citationSubsetIMlld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10051443pubmed:statusMEDLINElld:pubmed
pubmed-article:10051443pubmed:monthMarlld:pubmed
pubmed-article:10051443pubmed:issn0264-6021lld:pubmed
pubmed-article:10051443pubmed:authorpubmed-author:RocheP APAlld:pubmed
pubmed-article:10051443pubmed:authorpubmed-author:CushmanS WSWlld:pubmed
pubmed-article:10051443pubmed:authorpubmed-author:St-DenisJ FJFlld:pubmed
pubmed-article:10051443pubmed:authorpubmed-author:CabaniolsJ...lld:pubmed
pubmed-article:10051443pubmed:issnTypePrintlld:pubmed
pubmed-article:10051443pubmed:day15lld:pubmed
pubmed-article:10051443pubmed:volume338 ( Pt 3)lld:pubmed
pubmed-article:10051443pubmed:ownerNLMlld:pubmed
pubmed-article:10051443pubmed:authorsCompleteYlld:pubmed
pubmed-article:10051443pubmed:pagination709-15lld:pubmed
pubmed-article:10051443pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
pubmed-article:10051443pubmed:meshHeadingpubmed-meshheading:10051443...lld:pubmed
More...