| pubmed-article:10048029 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10048029 | lifeskim:mentions | umls-concept:C0038411 | lld:lifeskim |
| pubmed-article:10048029 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:10048029 | lifeskim:mentions | umls-concept:C0010853 | lld:lifeskim |
| pubmed-article:10048029 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:10048029 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:10048029 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
| pubmed-article:10048029 | lifeskim:mentions | umls-concept:C0449943 | lld:lifeskim |
| pubmed-article:10048029 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:10048029 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10048029 | pubmed:dateCreated | 1999-5-6 | lld:pubmed |
| pubmed-article:10048029 | pubmed:abstractText | A clonal variant of serotype M1 group A streptococcus (designated M1inv+) has been linked to severe and invasive infections, including sepsis, necrotizing fasciitis and toxic shock. High frequency internalization of cultured epithelial cells by the M1inv+ strain 90-226 is dependent upon the M1 protein. Invasion of HeLa cells was blocked by an anti-M1 antibody, invasion by an M1- strain (90-226 emm1::km) was greatly reduced, and latex beads bound to M1 protein were readily internalized by HeLa cells. Beads coated with a truncated M1 protein were internalized far less frequently. Scanning electron microscopy indicated that streptococci invade by a zipper-like mechanism, that may be mediated by interactions with host cell microvilli. Initially, internalized streptococci and streptococci undergoing endocytosis are associated with polymerized actin. Later in the internalization process, streptococcal-containing vacuoles are associated with the lysosomal membrane glycoprotein, LAMP-1. | lld:pubmed |
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| pubmed-article:10048029 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10048029 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10048029 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10048029 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10048029 | pubmed:issn | 0950-382X | lld:pubmed |
| pubmed-article:10048029 | pubmed:author | pubmed-author:LaiDD | lld:pubmed |
| pubmed-article:10048029 | pubmed:author | pubmed-author:ClearyP PPP | lld:pubmed |
| pubmed-article:10048029 | pubmed:author | pubmed-author:FinlayB BBB | lld:pubmed |
| pubmed-article:10048029 | pubmed:author | pubmed-author:CulMM | lld:pubmed |
| pubmed-article:10048029 | pubmed:author | pubmed-author:RuschkowskiSS | lld:pubmed |
| pubmed-article:10048029 | pubmed:author | pubmed-author:SedgewickJJ | lld:pubmed |
| pubmed-article:10048029 | pubmed:author | pubmed-author:DombekP EPE | lld:pubmed |
| pubmed-article:10048029 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10048029 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:10048029 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10048029 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10048029 | pubmed:pagination | 859-70 | lld:pubmed |
| pubmed-article:10048029 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10048029 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10048029 | pubmed:articleTitle | High-frequency intracellular invasion of epithelial cells by serotype M1 group A streptococci: M1 protein-mediated invasion and cytoskeletal rearrangements. | lld:pubmed |
| pubmed-article:10048029 | pubmed:affiliation | Department of Microbiology, University of Minnesota 55455, USA. | lld:pubmed |
| pubmed-article:10048029 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10048029 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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