| pubmed-article:10047537 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10047537 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:10047537 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:10047537 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:10047537 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10047537 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10047537 | pubmed:dateCreated | 1999-3-17 | lld:pubmed |
| pubmed-article:10047537 | pubmed:abstractText | Antigen processing by MHC class I molecules begins with the generation of peptides by proteolytic breakdown of proteins. IFN-gamma upregulates gene expression of several proteasomal subunits as well as the proteasome regulator PA28; this implicated their role in antigen degradation. Crystallographic, mutational and biochemical studies contributed to our understanding of the basic principles of proteasomal protein degradation and the consequences of IFN-gamma induction for proteasome function. In addition, nonproteasomal mechanisms seem to be involved in antigen degradation. Leucine aminopeptidase, which is also upregulated by IFN-gamma, was shown to collaborate with the proteasome for epitope production and unknown proteases seem to compensate for the loss of proteasomal degradation in the presence of proteasome inhibitors. Thus, a rather complex picture emerges for the rules governing peptide production in the presence or absence of IFN-gamma. | lld:pubmed |
| pubmed-article:10047537 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10047537 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10047537 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10047537 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10047537 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10047537 | pubmed:issn | 0952-7915 | lld:pubmed |
| pubmed-article:10047537 | pubmed:author | pubmed-author:YangYY | lld:pubmed |
| pubmed-article:10047537 | pubmed:author | pubmed-author:FrühKK | lld:pubmed |
| pubmed-article:10047537 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10047537 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:10047537 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10047537 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10047537 | pubmed:pagination | 76-81 | lld:pubmed |
| pubmed-article:10047537 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10047537 | pubmed:meshHeading | pubmed-meshheading:10047537... | lld:pubmed |
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| pubmed-article:10047537 | pubmed:meshHeading | pubmed-meshheading:10047537... | lld:pubmed |
| pubmed-article:10047537 | pubmed:meshHeading | pubmed-meshheading:10047537... | lld:pubmed |
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| pubmed-article:10047537 | pubmed:meshHeading | pubmed-meshheading:10047537... | lld:pubmed |
| pubmed-article:10047537 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10047537 | pubmed:articleTitle | Antigen presentation by MHC class I and its regulation by interferon gamma. | lld:pubmed |
| pubmed-article:10047537 | pubmed:affiliation | The R. W. Johnson Pharmaceutical Research Institute, General Atomics Court, San Diego, CA 92121, USA. kfrueh@prius.jnj.com. | lld:pubmed |
| pubmed-article:10047537 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10047537 | pubmed:publicationType | Review | lld:pubmed |
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