| pubmed-article:10037704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C0063740 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C0031586 | lld:lifeskim |
| pubmed-article:10037704 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10037704 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10037704 | pubmed:dateCreated | 1999-3-30 | lld:pubmed |
| pubmed-article:10037704 | pubmed:abstractText | The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent inducer of keratinocyte differentiation and of involucrin gene expression. In the present study we show that a CCAAT/enhancer-binding protein (C/EBP) site in the proximal regulatory region is required for the phorbol ester response. Mutation of the C/EBP site results in the loss of basal and TPA-responsive activity. Gel mobility supershift analysis shows that C/EBPalpha binding to this site is increased by TPA treatment. Moreover, cotransfection of the human involucrin reporter plasmid with C/EBPalpha increases promoter activity to an extent comparable with TPA treatment. Mutation of the C/EBP-binding site eliminates these responses. Transfection experiments using GADD153 to create C/EBP-null conditions confirm that C/EBP factors are absolutely required for promoter activity and TPA responsiveness. C/EBPbeta and C/EBPdelta inhibit both TPA- and C/EBPalpha-dependent promoter activation, indicating functional differences among C/EBP family members. These results suggest that C/EBP transcription factor activity is necessary for basal promoter activity and TPA response of the involucrin gene. | lld:pubmed |
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| pubmed-article:10037704 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10037704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10037704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10037704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10037704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10037704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10037704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10037704 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10037704 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10037704 | pubmed:author | pubmed-author:EckertR LRL | lld:pubmed |
| pubmed-article:10037704 | pubmed:author | pubmed-author:WelterJ FJF | lld:pubmed |
| pubmed-article:10037704 | pubmed:author | pubmed-author:AgarwalCC | lld:pubmed |
| pubmed-article:10037704 | pubmed:author | pubmed-author:CrishJ FJF | lld:pubmed |
| pubmed-article:10037704 | pubmed:author | pubmed-author:EfimovaTT | lld:pubmed |
| pubmed-article:10037704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10037704 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:10037704 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10037704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10037704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10037704 | pubmed:pagination | 6190-4 | lld:pubmed |
| pubmed-article:10037704 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:meshHeading | pubmed-meshheading:10037704... | lld:pubmed |
| pubmed-article:10037704 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10037704 | pubmed:articleTitle | CCAAT/enhancer-binding proteins. A role in regulation of human involucrin promoter response to phorbol ester. | lld:pubmed |
| pubmed-article:10037704 | pubmed:affiliation | Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970, USA. | lld:pubmed |
| pubmed-article:10037704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10037704 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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