| pubmed-article:10029452 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10029452 | lifeskim:mentions | umls-concept:C0152018 | lld:lifeskim |
| pubmed-article:10029452 | lifeskim:mentions | umls-concept:C0262584 | lld:lifeskim |
| pubmed-article:10029452 | lifeskim:mentions | umls-concept:C0205618 | lld:lifeskim |
| pubmed-article:10029452 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:10029452 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10029452 | pubmed:dateCreated | 1999-3-2 | lld:pubmed |
| pubmed-article:10029452 | pubmed:abstractText | We histologically examined undifferentiated small cell carcinoma of the esophagus from 21 patients and used immunohistochemical methods for detection of chromogranin A and p53, bcl-2, and Rb oncoproteins. Nine (43%) of the 21 carcinomas consisted solely of undifferentiated cells, but heterogeneous components of in situ or invasive squamous cell carcinoma or mucoepidermoid carcinoma were observed in the other 12 (57%) tumors. Squamous cell carcinoma in situ was observed in the mucosa adjacent to the main tumor in 7 (50%) of the 14 resected esophageal specimens. An admixture of invasive squamous cell carcinoma and undifferentiated carcinoma was observed in 4 (19%) of the 21 tumors, and mucoepidermoid carcinoma was noted in one case. Chromogranin A staining yielded a positive reaction in two (10%) undifferentiated components but was negative in all heterogeneous components. Multiple sites of p53 immunopositivity were seen in the undifferentiated component of 17 (81%) of the 21 tumors, as well as in the in situ or invasive squamous cell carcinoma or mucoepidermoid carcinoma components of 9 (75%) of 12 tumors. Seven (33%) of the 21 tumors showed positive bcl-2 immunoreactivity in the small cell component, but all of the heterogeneous components were negative. Rb protein immunoreactivity was observed in the small cell component of one (5%) case and in 9 (75%) of the 12 heterogeneous components. Six (86%) of the seven in situ squamous cell carcinoma components were positive for Rb protein. Eighteen (86%) of the 21 patients died within 24 months of diagnosis. Two patients (10%) who survived for more than 24 months had received chemotherapy. | lld:pubmed |
| pubmed-article:10029452 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10029452 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10029452 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10029452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10029452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10029452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10029452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10029452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10029452 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10029452 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10029452 | pubmed:issn | 0046-8177 | lld:pubmed |
| pubmed-article:10029452 | pubmed:author | pubmed-author:TanakaYY | lld:pubmed |
| pubmed-article:10029452 | pubmed:author | pubmed-author:NakamuraKK | lld:pubmed |
| pubmed-article:10029452 | pubmed:author | pubmed-author:SasajimaKK | lld:pubmed |
| pubmed-article:10029452 | pubmed:author | pubmed-author:MiyashitaMM | lld:pubmed |
| pubmed-article:10029452 | pubmed:author | pubmed-author:AraiTT | lld:pubmed |
| pubmed-article:10029452 | pubmed:author | pubmed-author:SawabeMM | lld:pubmed |
| pubmed-article:10029452 | pubmed:author | pubmed-author:MafuneKK | lld:pubmed |
| pubmed-article:10029452 | pubmed:author | pubmed-author:EsakiYY | lld:pubmed |
| pubmed-article:10029452 | pubmed:author | pubmed-author:TakuboKK | lld:pubmed |
| pubmed-article:10029452 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10029452 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:10029452 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10029452 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10029452 | pubmed:pagination | 216-21 | lld:pubmed |
| pubmed-article:10029452 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10029452 | pubmed:meshHeading | pubmed-meshheading:10029452... | lld:pubmed |
| pubmed-article:10029452 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10029452 | pubmed:articleTitle | Primary undifferentiated small cell carcinoma of the esophagus. | lld:pubmed |
| pubmed-article:10029452 | pubmed:affiliation | Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan. | lld:pubmed |
| pubmed-article:10029452 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10029452 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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