| pubmed-article:10028923 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C0007226 | lld:lifeskim |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C0030532 | lld:lifeskim |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C0234421 | lld:lifeskim |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10028923 | lifeskim:mentions | umls-concept:C0025991 | lld:lifeskim |
| pubmed-article:10028923 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10028923 | pubmed:dateCreated | 1999-5-6 | lld:pubmed |
| pubmed-article:10028923 | pubmed:abstractText | Activation of serotonin (5-hydroxytryptamine, 5-HT) receptors in the brain produces cardiovascular responses by altering autonomic outflow. The paraventricular nucleus (PVN) contains a modest density of 5-HT receptors and has connections to autonomic centers. Experiments were designed to determine whether cardiovascular responses were produced by the administration of 5-HT2- and 5-HT1A-receptor agonists into the PVN of conscious rats. The microinjection of the 5-HT2-receptor agonist DOI [(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl] into the PVN produced dose-dependent (1-10 nmol) increases in heart rate and blood pressure; the peak responses were +39 +/- 10 beats/min and +6 +/- 2 mm Hg, respectively. Both responses were blocked by the concomitant administration of the selective 5-HT2-receptor antagonist LY53857 into the PVN. By contrast, the microinjection of the selective 5-HT1A-receptor agonist R(+)-8-OH-DPAT [R(+)8-hydroxy-2-(di-n-propylamino) tetralin HBr; 1-10 nmol] into the PVN did not affect blood pressure or heart rate. These data suggest that 5-HT neurons projecting from the raphe nuclei to or near the PVN can participate in the central control of the cardiovascular system by way of 5-HT2 receptors. Apparently 5-HT neurons terminating in the PVN can increase blood pressure and heart rate and produce sympathoadrenal activation, metabolic and hormonal responses consistent with those observed in several different stress paradigms. | lld:pubmed |
| pubmed-article:10028923 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10028923 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10028923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028923 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10028923 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10028923 | pubmed:issn | 0160-2446 | lld:pubmed |
| pubmed-article:10028923 | pubmed:author | pubmed-author:AlperR HRH | lld:pubmed |
| pubmed-article:10028923 | pubmed:author | pubmed-author:BurtA AAA | lld:pubmed |
| pubmed-article:10028923 | pubmed:author | pubmed-author:BellA AAA | lld:pubmed |
| pubmed-article:10028923 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10028923 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:10028923 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10028923 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10028923 | pubmed:pagination | 175-80 | lld:pubmed |
| pubmed-article:10028923 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:meshHeading | pubmed-meshheading:10028923... | lld:pubmed |
| pubmed-article:10028923 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10028923 | pubmed:articleTitle | Cardiovascular responses produced by microinjection of serotonin-receptor agonists into the paraventricular nucleus in conscious rats. | lld:pubmed |
| pubmed-article:10028923 | pubmed:affiliation | Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City 66160-7417, USA. | lld:pubmed |
| pubmed-article:10028923 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10028923 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
