| pubmed-article:10026274 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10026274 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:10026274 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:10026274 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:10026274 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10026274 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:10026274 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:10026274 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10026274 | pubmed:dateCreated | 1999-3-4 | lld:pubmed |
| pubmed-article:10026274 | pubmed:abstractText | The abasic site is a common lesion in DNA that is also formed as an intermediate in the base excision repair of damaged bases. We have previously reported the adenine-acridine conjugate 1 that was designed to bind to the abasic site and interfere with the repair process. High-field NMR had shown that 1 forms specific complexes with a DNA duplex containing an apurinic abasic site model. We report here the dynamics of the interaction of the nitroxide-labeled analogue 3 of the conjugate 1 with the same apurinic oligonucleotide and with the parent unmodified duplex. Identical study of the labeled acridine subunit 5 used as a reference is also reported. In the presence of the apurinic duplex and depending on the concentrations and drug ratios, three species are observed: the radical "free in solution", the "intercalation" complex characterized by its similarity to that observed in the presence of the parent unmodified duplex, and the "abasic-site-specific" complex which is the sole species visible at low drug ratios. The experimental data reinforced by molecular modeling of the complex and theoretical calculation of correlation times suggest (i) the most immobilized form corresponds to that observed by NMR and (ii) complexation of the drug is little or not modified by the spin-label. We also show that the abasic site constitutes a binding site for the propylaminoacridine intercalator 5. | lld:pubmed |
| pubmed-article:10026274 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10026274 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10026274 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10026274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10026274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10026274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10026274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10026274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10026274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10026274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10026274 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10026274 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10026274 | pubmed:issn | 0006-2960 | lld:pubmed |
| pubmed-article:10026274 | pubmed:author | pubmed-author:LhommeJJ | lld:pubmed |
| pubmed-article:10026274 | pubmed:author | pubmed-author:MichonJJ | lld:pubmed |
| pubmed-article:10026274 | pubmed:author | pubmed-author:ThomasFF | lld:pubmed |
| pubmed-article:10026274 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10026274 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:10026274 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:10026274 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10026274 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10026274 | pubmed:pagination | 1930-7 | lld:pubmed |
| pubmed-article:10026274 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:meshHeading | pubmed-meshheading:10026274... | lld:pubmed |
| pubmed-article:10026274 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10026274 | pubmed:articleTitle | Interaction of a spin-labeled adenine-acridine conjugate with a DNA duplex containing an abasic site model. | lld:pubmed |
| pubmed-article:10026274 | pubmed:affiliation | L.E.D.S.S., Chimie Bioorganique, UMR CNRS 5616, Université Joseph Fourier, Grenoble, France. | lld:pubmed |
| pubmed-article:10026274 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10026274 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
