| pubmed-article:1000504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1000504 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:1000504 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1000504 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:1000504 | lifeskim:mentions | umls-concept:C0040284 | lld:lifeskim |
| pubmed-article:1000504 | lifeskim:mentions | umls-concept:C0014930 | lld:lifeskim |
| pubmed-article:1000504 | lifeskim:mentions | umls-concept:C0752229 | lld:lifeskim |
| pubmed-article:1000504 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1000504 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:1000504 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1000504 | pubmed:dateCreated | 1977-2-16 | lld:pubmed |
| pubmed-article:1000504 | pubmed:abstractText | We have established or characterized six lines of human breast cancer maintained in long-term tissue culture for at least 1 year and have examined these lines for estrogen responsiveness. One of these cell lines, MCF-7, shows marked stimulation of macromolecular synthesis and cell division with physiological concentrations of estradiol. Antiestrogens are strongly inhibitory, and at concentrations greater than 3 X 10(-7) M they kill cells. Antiestrogen effects are prevented by simultaneous treatment with estradiol or reversed by addition of estradiol to cells incubated in antiestrogen. Responsive cell lines contain high-affinity specific estradiol receptors. Antiestrogens compete with estradiol for these receptors but have a lower apparent affinity for the receptor than estrogens. Stimulation of cells by estrogens is biphasic, with inhibition and cell death at concentrations of 17beta-estradiol or diethylstilbestrol exceeding 10(-7) M. Killing by high concentrations of estrogen is probably a nonspecific effect in that we observe this response with 17alpha-estradiol at equivalent concentrations and in the otherwise unresponsive cells that contain no estrogen receptor sites. | lld:pubmed |
| pubmed-article:1000504 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1000504 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1000504 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1000504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1000504 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1000504 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:1000504 | pubmed:author | pubmed-author:LippmanMM | lld:pubmed |
| pubmed-article:1000504 | pubmed:author | pubmed-author:HuffKK | lld:pubmed |
| pubmed-article:1000504 | pubmed:author | pubmed-author:BolanGG | lld:pubmed |
| pubmed-article:1000504 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1000504 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:1000504 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1000504 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1000504 | pubmed:pagination | 4595-601 | lld:pubmed |
| pubmed-article:1000504 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:1000504 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:1000504 | pubmed:articleTitle | The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture. | lld:pubmed |
| pubmed-article:1000504 | pubmed:publicationType | Journal Article | lld:pubmed |
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