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The CLU domain (CLUstered mitochondria) is a eukaryotic domainfound in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport [1,2] although the exact function of the domain is unknown [4]. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane [2] suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast [1]. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre [1]. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure [3].
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