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B2 is expressed by the insect Flock House virus (FHV) as acounter-defense mechanism against antiviral RNA silencing during infection. In vitro, B2 binds to dsRNA as a dimer and inhibits the cleavage of it by Dicer. B2 blocks cleavage of the FHV genome by Dicer and also the incorporation of FHV small interfering RNAs into the RNA-induced silencing complex [1].
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B2
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RNA binding protein B2
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Pollington J
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Family
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